Uric Acid and Renal Pathological Features

New Orleans—Patients with chronic kidney disease (CKD) commonly develop hyperuricemia, which increases the risk of cardiovascular events and accelerates CKD progression. Chinese researchers conducted a study to identify the relationship between baseline uric acid levels and renal pathological features. The study included 1070 patients who underwent renal biopsy at a single center.

Of the 1070 patients, 429 were IgA nephropathy (IgAN) and 641were non-IgAN. The prevalence of hyperuricemia in the total cohort was 61.2% (n=655); in the IgAN cohort, the prevalence was 56.2% (n=241), and in the non-IgAN cohort, prevalence was 64.6% (n=414). Following adjustment for serum creatinine, multivariate logistic regression analysis demonstrated that hyperuricemia remained a risk factor for segmental glomerulosclerosis (odds ratio [OR], 1.783; 95 % confidence interval [CI], 1.327-2.397) and tubular atrophy or interstitial fibrosis (OR, 1.751; 95 % Ci, 1.00-2.941).

In summary, the researchers said, “Hyperuricemia is prevalent in CKD patients receiving renal biopsy. Uric acid correlates not only to clinical renal injury indexes including serum creatinine, estimated glomerular filtration rate, urine protein, but also to renal pathology. Hyperuricemia is independently associated with segmental glomerulosclerosis and tubular atrophy or interstitial fibrosis. Reduced uric acid levels may delay the progression of worsening renal function.”

Source: Wang L, Hong D. Uric acid and renal pathological features: a cross-sectional study of 1070 patients receiving renal biopsy. Abstract of a poster presented at the American Society of Nephrology 2017 Kidney Week, November 3, 2017, New Orleans, Louisiana.