Statin Therapy Reduces Occurrence of AKI after Angiography

New Orleans—The diagnosis and treatment of cardiovascular diseases is often complicated by the presence of acute kidney injury (AKI). Previous studies have demonstrated a significant decrease in the occurrence of AKI when patients were treated with statin therapy prior to coronary angiography and/or intervention; however, the association between pretreatment statin therapy and the occurrence of AKI in patients with peripheral artery disease is unknown. Researchers in Japan conducted a retrospective analysis to examine the association between statin therapy and the occurrence of AKI in patients with peripheral artery disease.

Daisuke Kanai, MD, reported results of the analysis during a poster session at Kidney Week 2017. The poster was titled Association between Statin Therapy and Occurrence of AKI in Patients with Peripheral Artery Diseases.

The researchers utilized data from the endovascular treatment database at Nishiwaki Municipal Hospital, Nishiwaki, Japan, to identify angiography and/or intervention performed for peripheral artery disease between October 2011 and March 2016 (n=377 patients). Of those, 69 patients with chronic kidney disease receiving hemodialysis and 13 lacking sufficient data were excluded.

The remaining 295 patients were divided into two groups: those who did not receive statin therapy (control group, n=157) and those who did receive statin therapy (statin group, n=138) for at least one month prior to admission. AKI was defined by absolute increase in serum creatinine of ≥0.5 mg/dL or a relative increase of ≥25% measured 1 week following the procedure.

Prior to the procedure, the two groups were similar in sex, serum creatinine level, amount of contrast medium, use of renin angiotensin system inhibitors, smoking, and blood pressure. Patients in the statin group were significantly younger, more likely to have diabetes mellitus, and more likely to have higher body mass index (BMI) and lower low-density lipoprotein cholesterol (LDL-C) than the control group (LDL-C, 100 mg/dL vs 108 mg/dL, respectively).

The incidence of AKI was significantly lower in the statin group compared with the control group (5% vs 16%, P<.05). In multivariate analyses adjusted for age, BMI, diabetes mellitus, LDL-C, serum creatinine, and statin therapy, statin therapy was significantly correlated with the lower occurrence of AKI (P<.05).

In conclusion, the researchers said, “The results of our study suggested that statin therapy may prevent the occurrence of AKI after angiography and/or intervention for peripheral artery disease.”

Source: Kanai D, Nakai K, Fujii H, Nishi S. Association between statin therapy and occurrence of AKI in patients with peripheral artery diseases. Abstract of a poster presented at the American Society of Nephrology 2017 Kidney Week, November 4, 2017, New Orleans, Louisiana.