Hyponatremia in Newly Diagnosed Dengue Infection

New Orleans—Guidelines from the Pan American Health Organization/World Health Organization issued in 2016 regarding dengue infection and recommendations for the US Centers for Disease Control and Prevention call for high water intake in patients with dengue virus infection. However, there are few data available on the prevalence of hyponatremia in patients newly infected with the virus.

Researchers in Argentina, led by Daniel Caputo, MD, conducted a cross-sectional study of patients with newly diagnosed dengue infection in Argentina from January 2016 to April 2016. Study results were reported during a poster session at Kidney Week 2017 in a poster titled Prevalence of Hyponatremia in Dengue Infected Patients.

The study defined hyponatremia as serum sodium concentration ≤135 mEq/L. Natremia was corrected in patients with hyperglycemia Patients with creatinine > 1.6 mg/dL were excluded from the study.

The researchers evaluated 146 patients with newly diagnosed dengue infection confirmed by immunoglobulin M serology or polymerase chain reaction. Of the 146 study participants, hyponatremia was present in 30.8%. Following adjustment for age and sex, in multivariate logistic regression models, the odds ratio (OR) of hyponatremia was significant in patients >65 years of age (OR 9.2; 95% confidence interval, 2.9-28.9; P=.001).

The researchers said, “The prevalence of hyponatremia in newly infected patients with dengue, especially in older patients, is high. Electrolyte evaluation should be done at admission in all patients with dengue and routine use of hypnotic fluids should be avoided in these patients.”

Source: Caputo D, Negro AL, Ayus JC, Eghi C, Cabral GE, carreño Fernandez Y. Prevalence of hyponatremia in dengue infected patients. Abstract of a poster presented at the American Society of Nephrology 2017 Kidney Week, November 2, 2017, New Orleans, Louisiana.