Online Exclusives

Variability of Rates of Hyperkalemia among Patients on Hemodialysis

Orlando—Patients with end-stage renal disease have a high prevalence of cardia arrhythmias and sudden death. Patients more commonly experience hyperkalemia during the long inter-dialytic period, creating an association with increased mortality. Bhupinder Singh, MD, and colleagues recently conducted a prospective, observational study designed to examine the incidence of hyperkalemia, defined as serum potassium >5.0 mEq/L, as well as hypokalemia, and ... Read More »

Hospitalization and Emergency Department Visit Rates in Medicare Hemodialysis Patients

Orlando—Prevalent hemodialysis patients covered by Medicare have declining rates of hospitalization; however, rates of emergency department encounters and admissions for observation have increased. Researchers, led by David Gilbertson, recently conducted an analysis of concurrent trends of those acute encounters with the healthcare system in that patient population. Results of the analysis were reported during a poster session at the NKF ... Read More »

Hyponatremia in a Small Cell Lung Cancer Patient: A Case Study

Orlando—Patients with small cell lung cancer may develop euvolemic hyponatremia due to low solute intake, syndrome of inappropriate antidiuretic hormone secretion (SIADH), or renal salt wasting from a platinum-based alkylating agent. Renal tubular injury, salt-magnesium and potassium-wasting have been associated with cisplatin; carboplatin, with a relatively lower nephrotoxic profile, is considered a safer alternative. Omar Rabadi, MD, and colleagues presented ... Read More »

Admission Serum Potassium Level and In-Hospital Mortality

Orlando—Wisit Cheungpasitporn and colleagues at the Mayo Clinic in Rochester, Minnesota, recently conducted a single-center retrospective study designed to examine the relationship between serum potassium levels and in-hospital mortality. The study included all hospitalized patients at a tertiary referral hospital. Study results were reported during a poster session at the NKF 2017 Spring Clinical Meetings in a poster titled Admission ... Read More »

Sodium Bicarbonate Reduces Inter-Hemodialysis Potassium Gain

Chicago—One of the adverse effects of hemodialysis on clinical outcomes is associated with the intermittent nature of the therapy; increased mortality rates are related to long intervals between sessions. One reason for adverse effects of long intervals between therapy is high levels of potassium, however, according to researchers in the United Kingdom, low potassium levels post-hemodialysis can cause arrhythmias. Stella ... Read More »

Reduction in Pill Burden with Switch to Phosphate Binder Monotherapy

Orlando—Stuart M. Sprague, MD, and colleagues recently conducted an analysis of adult patients on hemodialysis who switched from baseline phosphate binder dual therapy with calcium acetate, sevelamer, or lanthanum carbonate to monotherapy with sucroferric oxyhydroxide as part of routine care. The analysis was designed to examine changes in serum phosphorus as well as pill burden for hemodialysis patients. The researchers ... Read More »

Phosphate-Containing Replacement Solution for Hypophosphatemia in CRRT

Chicago—Patients undergoing continuous renal replacement therapy (CRRT) often experience hypophosphatemia, requiring treatment with intravenous infusion of phosphate-containing solutions. Conventional replacement solutions do not contain any phosphate. However, there are now replacement solutions that do contain phosphate. There are few data available on optimal use of phosphate-containing replacement solutions. Farah N. Ali, MD, and colleagues recently conducted an analysis designed to ... Read More »

Hyponatremia Risk Independent Factor for Kidney Stones

Chicago—Results of previous studies have shown an association between hyponatremia and increased risk for osteoporosis and bone fractures, conditions that are also associated with kidney stones. Up to 80% of a kidney stone in predominately composed of calcium oxalate, and urinary oxalate is a major risk factor for calcium oxalate kidney stone formation. Naoto Tominaga, MD, and colleagues recently conducted ... Read More »

High Pill Burden Reduces Adherence and Quality of Life

Chicago—Among patients struggling to manage complications associated with chronic kidney disease (CKD), pill burden is a common problem. James Jackson, MD, and colleagues recently conducted an analysis designed to determine whether there is a link between increased pill burden and decreased adherence to medication regimen. The researchers also sought to examine whether increased pill burden has an impact on patient ... Read More »

SPRINT: Kidney Disease Associated with Cognitive Impairment

Chicago—There are few data available regarding the relationship between kidney disease and a high risk of cognitive impairment. To examine the relationship among kidney disease, cognitive functions, and cerebrovascular disease, Daniel E. Weiner, MD, and colleagues recently conducted an analysis of data from the SPRINT (Systolic Blood Pressure Intervention) cognition substudy, SPRINT-MIND. The researchers reported results of the analysis during ... Read More »