Online Exclusives

Reduction in Pill Burden with Switch to Phosphate Binder Monotherapy

Orlando—Stuart M. Sprague, MD, and colleagues recently conducted an analysis of adult patients on hemodialysis who switched from baseline phosphate binder dual therapy with calcium acetate, sevelamer, or lanthanum carbonate to monotherapy with sucroferric oxyhydroxide as part of routine care. The analysis was designed to examine changes in serum phosphorus as well as pill burden for hemodialysis patients. The researchers ... Read More »

Sodium Bicarbonate Reduces Inter-Hemodialysis Potassium Gain

Chicago—One of the adverse effects of hemodialysis on clinical outcomes is associated with the intermittent nature of the therapy; increased mortality rates are related to long intervals between sessions. One reason for adverse effects of long intervals between therapy is high levels of potassium, however, according to researchers in the United Kingdom, low potassium levels post-hemodialysis can cause arrhythmias. Stella ... Read More »

Phosphate-Containing Replacement Solution for Hypophosphatemia in CRRT

Chicago—Patients undergoing continuous renal replacement therapy (CRRT) often experience hypophosphatemia, requiring treatment with intravenous infusion of phosphate-containing solutions. Conventional replacement solutions do not contain any phosphate. However, there are now replacement solutions that do contain phosphate. There are few data available on optimal use of phosphate-containing replacement solutions. Farah N. Ali, MD, and colleagues recently conducted an analysis designed to ... Read More »

Hyponatremia Risk Independent Factor for Kidney Stones

Chicago—Results of previous studies have shown an association between hyponatremia and increased risk for osteoporosis and bone fractures, conditions that are also associated with kidney stones. Up to 80% of a kidney stone in predominately composed of calcium oxalate, and urinary oxalate is a major risk factor for calcium oxalate kidney stone formation. Naoto Tominaga, MD, and colleagues recently conducted ... Read More »

High Pill Burden Reduces Adherence and Quality of Life

Chicago—Among patients struggling to manage complications associated with chronic kidney disease (CKD), pill burden is a common problem. James Jackson, MD, and colleagues recently conducted an analysis designed to determine whether there is a link between increased pill burden and decreased adherence to medication regimen. The researchers also sought to examine whether increased pill burden has an impact on patient ... Read More »

SPRINT: Kidney Disease Associated with Cognitive Impairment

Chicago—There are few data available regarding the relationship between kidney disease and a high risk of cognitive impairment. To examine the relationship among kidney disease, cognitive functions, and cerebrovascular disease, Daniel E. Weiner, MD, and colleagues recently conducted an analysis of data from the SPRINT (Systolic Blood Pressure Intervention) cognition substudy, SPRINT-MIND. The researchers reported results of the analysis during ... Read More »

Sodium Bicarbonate Reduces Inter-Hemodialysis Potassium Gain

Chicago—One of the adverse effects of hemodialysis on clinical outcomes is associated with the intermittent nature of the therapy; increased mortality rates are related to long intervals between sessions. One reason for adverse effects of long intervals between therapy is high levels of potassium, however, according to researchers in the United Kingdom, low potassium levels post-hemodialysis can cause arrhythmias. Stella ... Read More »

Factors Associated with Home Hemodialysis Use and Discontinuation

Boston—Compared with patients who receive hemodialysis in a dialysis center, those who undergo home hemodialysis have more time on dialysis and experience better outcomes, including quality of life, blood pressure control, mineral metabolism, fewer cardiovascular-related hospitalizations, and overall survival. However, currently fewer than 2% of dialysis patients in the United States use home hemodialysis. Possible factors contributing to the low ... Read More »

Hyponatremia Associated with Osteoporosis and Fracture

Boston—Previous studies have shown an association between hyponatremia, a common electrolyte disorder, and osteoporosis and bone fracture. However, according to Anawin Sanguankeo, MD, and colleagues, there are few data clarifying whether hyponatremia directly associates with osteoporosis and fracture or if it is a surrogate marker of other causes. The researchers conducted a systematic review and meta-analysis of observational studies designed ... Read More »

Include Adrenal Insufficiency in Differential for Hyponatremia

Boston—Patients with hyponatremia due to adrenal insufficiency usually present with hypotension, hyperkalemia, hypercalcemia, and hypoglycemia. Patients with SIADH (syndrome of inappropriate antidiuretic hormone secretion) are euvolemic and normotensive. During a poster session at the NKF Spring Clinical Meetings, Avantika Chenna, MD, and colleagues described a case history of a patient with hyponatremia due to adrenal insufficiency who presented without the ... Read More »