Mineral Handling in Hemodialysis Patients

There is an association between chronic kidney disease (CKD) and an increased risk of cardiovascular morbidity and mortality. In patients with CKD, increased circulating concentrations of phosphate and fibroblast growth factor-23 (FGF23) are highly predictive of cardiovascular disease. In order to maintain long-term calcium and phosphate balance, in healthy individuals an ingested mineral load is acutely buffered by a rapidly ... Read More »

Protein-Energy Wasting More Prevalent in Women and Increases with Age

Approximately one-third of older adults in Europe are classified as malnourished upon admission to the hospital. Many patients also have chronic kidney disease (CKD), making nutritional problems more complex compared with those without CKD. Protein-energy easting (PEW) is defined as inadequate nutrient intake, in combination with other factors including inflammation, acidosis, and endocrine disorders that lead to increased net breakdown ... Read More »

Post Hoc Analysis of HALT-PKD Data Examines Patterns of Kidney Function Decline

An estimated one in 400 to 1000 individuals in the United States and more than 12 million worldwide are affected by autosomal dominant polycystic kidney disease (ADPKD). The predominant causative genes are PKD1 on chromosome 16 and PKD2 on chromosome 4. For patients with PKD1 genotype, mean age at onset of end-stage renal disease (ESRD) is 56 years; for patients ... Read More »

Study Protocol: Outcomes in Dialysis Patients with Aortic Stenosis

Worldwide, the number of patients receiving maintenance dialysis is increasing. Diabetic nephropathy and hypertensive kidney disease account for many of these patients. In addition, chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease, which leads to difficulty with dialysis therapy. While coronary heart disease is typical among patients with cardiovascular disease, patients on dialysis are increasingly being ... Read More »

Time Trends in ESRD in France and Forecast to the Year 2030

Due to the increasing number of patients in France with end-stage renal disease (ESRD) requiring renal replacement therapy (RRT), the management of ESRD is a top public health priority. As of December 31, 2015, there were 82,295 patients receiving RRT: 54% of those were on dialysis and 46% were living with a functional renal transplant.  Overall, the crude prevalence was ... Read More »

“New Deal” for Kidney Care for US Veterans Outlined

Results of recent analyses have shown that veterans receiving care from the Department of Veterans Affairs (VA) healthcare system are experiencing improvements in kidney health outcomes. Susan T. Crowley, MD, and Katherine Murphy, MHSA, employees of the Veterans Health Administration, suggest that “scrutiny of the agency’s current care model may identify population health initiatives associated with improved outcomes that could ... Read More »

Study Finds Antibiotic Use Linked to Kidney Stone Risk

Use of certain oral antibiotics may be linked to the growing incidence of kidney stone formation, according to a study recently published in the Journal of the American Society of Nephrology. Conducted by researchers at the Children’s Hospital of Philadelphia (CHOP), this study found that younger patients who were exposed to antibiotics were at the highest risk of developing kidney ... Read More »

Anemia Prevalence and Treatment Patterns in Patients with NDD-CKD

Patients with non-dialysis-dependent (NDD) chronic kidney disease (CKD) commonly experience anemia; as CKD worsens, the prevalence of anemia increases in that patient population. Data of the prevalence of anemia in patients with NDD-CKD are from the 2007-20210 National Health and Nutrition Examination Survey (NHANES). NHANES data are representative of the population in the United States. However, the sample size is ... Read More »

COMPASS: Protocol of a Study of Kidney Function and Diabetes in Rural New Mexico

Due to socioeconomic factors and limited access to primary and specialist care, the distribution of chronic kidney disease (CKD) in the United States is disproportionate in rural areas. Early CKD diagnosis and care, which are both difficult in rural areas, can slow the progression of the CKD to end-stage renal disease (ESRD). When patients do develop ESRD, those residing in ... Read More »

Assessment for Risk of Decline in Kidney Function after a Hypertensive Disorder of Pregnancy

In approximately 10% of all pregnancies, women develop hypertensive disorders, a major cause of maternal morbidity and mortality worldwide. Hypertensive disorders of pregnancy (HDP) occur on a spectrum that ranges from the mild form of gestational hypertension to preeclampsia, clinically characterized by the presence of hypertension in combination with proteinuria, other organ disturbances, and/or intrauterine growth restriction in the second ... Read More »