Association of Age with Risk Factors for AKI

Age is a determining factor for acute kidney injury (AKI); however, according to Sandra L. Kane-Gill, PharmD, MSc, and colleagues, the risk for AKI in older adults has not been systematically assessed. The researchers conducted a retrospective analysis of data from July 2000 through September 2008 to examine the exposures and underlying susceptibilities for AKI in older adults compared with ... Read More »

Lower Creatinine Clearance Associated with Muscle Atrophy Over Time

Chronic inflammation, protein-energy wasting, and progressive loss of muscle mass and strength are all associated with chronic kidney disease (CKD).  Adverse health outcomes resulting from reduced kidney function are “analogous to accelerated aging,” according to Baback Roshanravan, MD, MS, and colleagues. “Clinical consequences of these adverse physiologic processes associated with reduced kidney function include impaired ambulation, frailty, disability, and premature ... Read More »

Racial/Ethnicity Differences in Initial Hemodialyis Access

Compared with white patients, black patients and Hispanic patients tend to initiate hemodialysis with an arteriovenous fistula (AVF) less frequently. That was among the findings of a retrospective analysis conducted recently by Devin S. Zarkowsky, MD, and colleagues. Analysis results were reported online in JAMA Surgery [doi:10.1000/jamasurg.2015.0287]. Use of AVF at first hemodialysis has been shown to be associated with ... Read More »

Case Report of a Kidney Transplant Patient with Hemorrhagic Colitis

In post-transplant immunocompromised patients, cytomegalovirus (CMV) is a common viral infection. CMV can present in various ways, including colitis, gastritis, hepatitis, and leukopenia. Mujtaba Hasnain, MD, FACP, and colleagues in the Department of Transplant Nephrology at Saint Barnabas Medical Center, Livingston, New Jersey, presented a case report of a patient with severe hemorrhagic colitis due to CMV infection during a ... Read More »

Accuracy of Sestamibi Scans to Determine Parathyroid Pathology Examined

Patients who undergo kidney transplantation may develop tertiary hyperparathyroidism (ThPT) after successful renal transplantation. The incidence of ThPT, typically described as persistent hyperparathyroidism, may be as high as 50% in renal transplantation patients. The hyperparathyroidism often resolves in a few months following transplant, with or without medical treatment. The occurrence of ThPT increases with the duration of dialysis before transplantation ... Read More »

Gene Expression Profiles in Kidney Cell Types Associated with Fabry Disease

Findings from a recent study suggest that globotriaosylceramide (Gb3) and deacylated Gb3 (lyco-Gb3) lead to renal fibrosis in Fabry disease through different biochemical modulations. YJ Shin, MD, and colleagues reported study results online in Molecular Medicine Reports [doi:10.3892/mmr.2015.4010. Epub ahead of print]. Fabry disease is an X-linked lysosomal storage disorder caused by mutations in the gene encoding the a-galactosidase A ... Read More »

September 2015: Abstract Roundup

DIABETES Finerenone Improves Urinary-Creatinine Ratio                                              JAMA. 2015;314(9):884-894. For patients with diabetic nephropathy who receive an angiotensin-converting enzyme inhibitor (ACEI) or an angiotensin receptor blocker (ARB), the addition of the medication finerenone resulted in improvement in albuminuria compared with placebo in a recent study. George L. Bakris, MD, and colleagues designed the study to evaluate the safety and efficacy of varying ... Read More »

Short Survey Identifies Gaps in Sodium Reduction Awareness

Patients with chronic kidney disease (CKD) often benefit from changes in diet, including reductions in intake of dietary sodium. In patients with pre-dialysis CKD, reducing dietary sodium intake prevents cardiovascular events and reduces hypertension and proteinuria associated with kidney failure. However, although there are guidelines in place to limit daily intake of sodium, consumption of dietary sodium in patients with ... Read More »

Using Medicare Claims to Identify Older Adults with CKD

Data from a recent analysis suggest that most of the individuals with Medicare claims for chronic kidney disease (CKD) have reduced estimated glomerular filtration rate (eGFR) or albuminuria. Further, CKD, defined in claims or via measurements of eGFR and albumin-creatinine ratio (ACR), is associated with increased risk for end-stage renal disease and all-cause mortality. Those were among the findings of ... Read More »

Accuracy of Routine Serum Creatinine Measurements

In a recent study designed to examine the accuracy and intra-laboratory variation of serum creatinine (Scr) measurements in laboratories in Flanders, the researchers found that large inter-assay differences still exist. The study, conducted by Liesbeth Hoste, and colleagues, also sought to assess the effect of a variation in Scr concentration results on the calculated glomerular filtration rate (GFR) and the ... Read More »