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Renal Blood Flow and Oxygenation in Patients with CKD

A larger reduction of measured glomerular filtration rate (mGFR) than renal artery blood flow is characteristic in people with stable chronic kidney disease (CKD) stages 3 to 4. That was among the findings of a cross-sectional study conducted recently by Dinah S. Khartir, MD, PhD, and colleagues. Study results were reported in the American Journal of Kidney Diseases [2015;66(3):402-411]. According ... Read More »

Low Medication Adherence Associated with Adverse Safety Events

In those with estimated glomerular filtration rates (eGFRs) <60 mL/min/1.73 m2, there is an association between lower medication adherence and adverse safety events. That was the primary finding of a cross-sectional baseline analysis of a prospective cohort conducted by Kailin L. Hsu, BS, and colleagues. The researchers reported results of the analysis in the American Journal of Kidney Diseases [2015;66(4):621-629]. ... Read More »

Finerenone Improves the Urinary Albumin-Creatinine Ratio in Patients with Diabetic Nephropathy

In patients with diabetic nephropathy, most receiving an angiotensin-converting enzyme (ACE) inhibitor or an angiotensin receptor blocker (ARB), there was improvement in the urinary albumin-creatinine ratio with the addition of finerenone compared with placebo. That was the primary finding of a randomized, double-blind, placebo-controlled, parallel-group study conducted by George L. Bakris, MD, and colleagues. The researchers reported their findings in ... Read More »

Dental Health and Mortality in Patients with End-Stage Kidney Disease

Patients with chronic kidney disease (CKD) experience more extensive dental disease compared with individuals in the general population. It is unknown, however, whether dental health and behaviors are associated with survival among patients with end-stage renal disease receiving hemodialysis. Suetonia C. Palmer, PhD, and colleagues recently conducted the Oral-D (Oral Disease in Hemodialysis) Study to examine whether disease using standardized ... Read More »

Exercise-Based Interventions Improve Vascular Health in Transplant Recipients

Among kidney transplant recipients, cardiovascular disease (CVD) is the leading cause of death. Researchers recently conduced a pilot study that examined the potential effect of aerobic training or resistance training on vascular health in that patient population. Sharlene A. Greenwood, PhD, and colleagues reported on results of the EXERT (Exercise in Renal Transplant) trial in the American Journal of Kidney ... Read More »

Creation of Hemodialysis AV Access after Transplant Failure

Among patients with failed kidney transplants in Ontario, Canada, creation of arteriovenous (AV) vascular access is low, both before and after initiation of hemodialysis therapy. That was the primary finding of a retrospective cohort study conducted recently by Joyce C. Zhang, BSc (Pharm), and colleagues. Study results were reported in the American Journal of Kidney Diseases [2015;66(4):646-654]. For patients with ... Read More »

November/December 2015 Abstract Roundup

ACUTE KIDNEY INJURY Predicting Renal Recovery in Patients with AKI Clinical Nephrology. 2015 September 23. doi:10.5414/CN108635. There have been significant improvements in the epidemiology of acute kidney injury (AKI); however, no reliable method to predict renal recovery has been validated. Researchers led by Liang Wang, MD, used criteria from the Acute Kidney Injury Network (AKIN) to test whether concentrations of ... Read More »

Risk of AKI in Females Related to Baseline Health

Dallas—Up to 30% of patients undergoing cardiac surgery experience acute kidney injury (AKI). AKI is associated with an increased risk of infection and extended hospital length-of-stay. Further, AKI-associated mortality ranges from 15% to 30%. Previous intensive care unit studies have found a lower risk of AKI in women compared with men. However, following cardiac surgery, the risk of AKI in ... Read More »

CAD Management in Patients with Chronic Kidney Disease

Dallas—Researchers at Staten Island University Hospital, Staten Island, New York, recently conducted a retrospective cohort study to provide a basis for the management of coronary artery disease (CAD) in patients with chronic kidney disease (CKD). Marc Saad, MD, and colleagues reported results of the study during a poster session at the NFK 2015 Spring Clinical Meetings. The poster was titled ... Read More »

Risk of Hemorrhage Higher in Warfarin Users with CKD

Patients with lower estimated glomerular filtration rates (eGFRs) have differentially higher hemorrhage risk at international normalized ratio (INR) ≥4. That was among the findings of a prospective cohort study conducted recently by Nita A. Limdi, PharmD, PhD, and colleagues. The researchers reported their findings in the American Journal of Kidney Diseases [2015;65(5):701-709]. Warfarin, the most commonly prescribed oral anticoagulant, presents ... Read More »