News

Assessment of an Educational Intervention to Increase Transplant Knowledge

There are approximately 637,000 patients in the United States with end-stage renal disease (ESRD) or kidney failure. The two options for patients with ESRD to sustain life are dialysis or kidney transplantation from a living or deceased donor. Kidney transplantation, particularly from a living donor, is associated with 6 to 16 additional years of life and improved quality-of life versus ... Read More »

Risk of Cancer-Related Death Elevated in Solid-Organ Transplant Recipients

The cancer death rate was increased in recipients of a solid-organ transplant in a population-based cohort study conducted recently by Sergio A. Acuna, MD, and colleagues. The researchers reported study results online in JAMA Oncology [doi:10.1001/jamaoncol.2015.5137]. Previous studies have shown that compared with the general population, recipients of a solid-organ transplant have increased incidence of malignant neoplasm following transplantation. However, ... Read More »

January/February 2016 Abstract Roundup

CHRONIC KIDNEY DISEASE Biomarker in Urine Predicts CKD Progression Science Translational Medicine. 2015;7(316):p316ra193. Worldwide, 8% to 16% of the population is affected by chronic kidney disease (CKD), an incidence that is increasing, along with the number of patients progressing to end-stage kidney disease (ESKD). At present, it is difficult to predict which patients in the early stages of CKD will ... Read More »

Buffered Crystalloid Fluid versus Saline in the ICU: What It means for AKI Risk

Among patients in the intensive care unit (ICU) receiving crystalloid fluid therapy, there was no association between use of a buffered crystalloid compared with saline and risk of acute kidney injury (AKI). That was the primary finding of a double-blind, cluster randomized, double-crossover trial conducted recently by Paul Young, FCICM, and colleagues. The researchers reported results online in JAMA [doi:10.1001/jama.2015.12334]. ... Read More »

Study Finds Wide Geographic Variation in ESRD Care

Across the United States, there is wide regional variation in functional incident arteriovenous fistula (AVF) frequency and adjusted end-stage renal disease (ESRD) mortality. That was among the findings of a study conducted recently by Devin S. Zarkowsky, MD, and colleagues. The researchers reported results of the retrospective analysis in JAMA Surgery [2015; 150(8):764-770]. When used at first hemodialysis, survival in ... Read More »

Long-Term Mortality Rates in the Frequent Hemodialysis Network Nocturnal Trial

Among patients in the Frequent Hemodialysis Network (FHN) Nocturnal Trial, those assigned to frequent nocturnal hemodialysis had higher mortality rates than those assigned to conventional dialysis. That was the primary finding of a post-trial observational study conducted by Michael V. Rocco, MD, MSCE, and colleagues and reported in the American Journal of Kidney Diseases [2015;66(3):459-468]. The FHN Nocturnal Trial was ... Read More »

Kidney Function and Survival in Older Patients after Rehabilitation Stay

In older patients discharged from inpatient rehabilitation, estimated glomerular filtration rate (eGFR) category and Barthel score are independent risk factors for survival; however, advanced chronic kidney disease (CKD) does not preclude successful rehabilitation. That was among the findings of an analysis conduced recently by Edward M. Doyle and colleagues reported in the American Journal of Kidney Diseases [2015;66(50:768-774]. With advancing ... Read More »

Causes of Death in Patients with CKD and Diabetes in TREAT

Lower baseline glomerular filtration rate (GFR) and higher protein-creatinine ratio (PCR) were associated with both higher cardiovascular (CV) and non-CV mortality rates. That finding, from a study conducted recently, was particularly significant in cases of sudden death and in infection-related mortality. David M. Charytan, MD, MSc, and colleagues reported results of the retrospective analysis of data from a prospective randomized ... Read More »

Lower eGFRs and higher ACRs Associated with Higher Risks of AKI

In a recent meta-analysis, researchers found that among individuals with or without either diabetes mellitus or hypertension, lower estimated glomerular filtration rates (eGFRs) and high albuminuria are associated with higher risks of acute kidney injury (AKI). Matthew T. James, MD, PhD, and colleagues reported results of the analysis in the American Journal of Kidney Diseases [2015;666(4):602-612]. The incidence of AKI ... Read More »

Increased Albuminuria and Reduced eGFR Associated with Risk of AKI

Stratification of the risk of acute kidney injury (AKI) by kidney measures, such as estimated glomerular filtration rate (eGFR) and albumin-creatinine ratio (ACR), may be more useful than factors such as age, sex, or race. That was the primary finding of a collaborative meta-analysis performed recently by Morgan E. Grams, MD, PhD, and colleagues. The researchers reported their findings in ... Read More »