Vitamin K Insufficiency Associated with Increased Risk of Mortality

There is an independent association between vitamin K insufficiency and increased risk of mortality among stable kidney transplant recipients. That was the primary finding of an observational study conducted recently by Charlotte A. Keyzer, MD, and colleagues. Study results were reported in the American Journal of Kidney Diseases [2015;65(3):474-483]. The prognosis of patients with end-stage renal disease is substantially improved ... Read More »

Monotherapy with ACE Inhibitor and Blood pressure Control in Patients with ADPKD

In most patients with autosomal dominant polycystic kidney disease (ADPKD) and stage 3 chronic kidney disease, monotherapy with an angiotensin-converting enzyme (ACE) inhibitor was associated with blood-pressure control in a trial conducted recently by Vicente E. Torres, MD, PhD, and colleagues. The researchers reported the findings online in the New England Journal of Medicine [2014. doi:10.1056/NEJMoal402686]. In patients with ADPKD, ... Read More »

Executive Function Associated with Increased Mortality Risk in Hemodialysis Patients

Worse cognitive function, particularly worse executive function, is associated with a higher risk of mortality in patients on maintenance hemodialysis. This relationship may be partially associated with the burden of cerebrovascular disease. Those were the primary findings of a study conducted recently by David A. Drew, MD, and colleagues. The researchers reported study results in the American Journal of Kidney ... Read More »

Peritoneal Dialysis Patients Have Low Mortality but High Morbidity

In a study reported in the American Journal of Kidney Diseases [2014;64(5):761-769], Joseph Pulliam, MD, and colleagues reported that despite low mortality rates among patients initiating renal replacement therapy with peritoneal dialysis (PD), incident PD patients had high morbidity, particularly within the first 3 to 6 months. Compared with other countries, the prevalence of PD therapy in the United States ... Read More »

Vascular Access Type Associated with Inflammation

The CHOICE (Choices for Healthy Outcomes in Caring for ESRD [end-stage renal disease]) study was designed to examine the role of access on serial levels of inflammatory markers. Results of the study, reported in the American Journal of Kidney Diseases, support recommendations for the early removal or avoidance of central venous catheter (CVC) placement. Tanushree Banerjee, PhD, and colleagues conducted ... Read More »

ESA Use Before and After TREAT

In 1989, the US FDA approved erythropoiesis-stimulating agents (ESAs) such as epoetin alfa (erythropoietin) to treat anemia associated with kidney disease. It was not until October 2009 that the first placebo-controlled ESA trail in patients with chronic kidney disease (CKD) with hard outcomes was published, according to Mae Thamer, PhD, and colleagues in an article in the American Journal of ... Read More »

NKF Holds Spring Clinical Meetings

The National Kidney Foundation held its 2015 Spring Clinical Meetings in Dallas, Texas, March 25-29. The meeting was an opportunity for renal health care providers to learn new developments related to all aspects of nephrology. It was designed for kidney doctors in the private sector and academia, fellows and residents with a special interest in kidney disease, general internists, pharmacists, ... Read More »

Stem-Cell Based Therapy and Anti-Scarring Agent May Reverse Kidney Scarring

Researchers at Monash University in Melbourne, Australia, have demonstrated the effectiveness of a combination of stem-cell based therapy with an anti-scarring agent to reverse scarring and markers of kidney injury, reducing the need for dialysis or transplantation. According to an article in Medical News Today, the researchers found that adult stem cells, combined with a protein called serelaxin, can reverse ... Read More »

Aerospace May Help Develop Improved Arteriovenous Fistula

An interdisciplinary team of researchers in the United Kingdom has redesigned an artificial arteriovenous fistula. According to an article in Medical News Today, the design may decrease the likelihood of blockages in arteriovenous fistulas, a major complication of dialysis. The researchers utilized computational simulation software developed originally for the aerospace sector to simulate and predict flow patterns in various arteriovenous ... Read More »

Kidney Disease May Not Prevent Positive Outcomes of EVAR

Patients at high-risk for surgery can benefit from surgical repair of an abdominal aortic aneurysm, according to results of a recent study reported in Medical News Today. Risk factors examined in the study included advanced age, diabetes, smoking, and kidney disease. The study assessed the risks associated with endovascular aneurysm repair (EVAR), a minimally invasive procedure. Study results were reported ... Read More »