November/December 2015 Abstract Roundup

ACUTE KIDNEY INJURY Predicting Renal Recovery in Patients with AKI Clinical Nephrology. 2015 September 23. doi:10.5414/CN108635. There have been significant improvements in the epidemiology of acute kidney injury (AKI); however, no reliable method to predict renal recovery has been validated. Researchers led by Liang Wang, MD, used criteria from the Acute Kidney Injury Network (AKIN) to test whether concentrations of ... Read More »

Risk of AKI in Females Related to Baseline Health

Dallas—Up to 30% of patients undergoing cardiac surgery experience acute kidney injury (AKI). AKI is associated with an increased risk of infection and extended hospital length-of-stay. Further, AKI-associated mortality ranges from 15% to 30%. Previous intensive care unit studies have found a lower risk of AKI in women compared with men. However, following cardiac surgery, the risk of AKI in ... Read More »

CAD Management in Patients with Chronic Kidney Disease

Dallas—Researchers at Staten Island University Hospital, Staten Island, New York, recently conducted a retrospective cohort study to provide a basis for the management of coronary artery disease (CAD) in patients with chronic kidney disease (CKD). Marc Saad, MD, and colleagues reported results of the study during a poster session at the NFK 2015 Spring Clinical Meetings. The poster was titled ... Read More »

Risk of Hemorrhage Higher in Warfarin Users with CKD

Patients with lower estimated glomerular filtration rates (eGFRs) have differentially higher hemorrhage risk at international normalized ratio (INR) ≥4. That was among the findings of a prospective cohort study conducted recently by Nita A. Limdi, PharmD, PhD, and colleagues. The researchers reported their findings in the American Journal of Kidney Diseases [2015;65(5):701-709]. Warfarin, the most commonly prescribed oral anticoagulant, presents ... Read More »

Algorithm for Prediction of AVF Failure to Mature

Dallas—Current practice guidelines from the National Kidney Foundation’s Kidney Disease Outcomes Quality initiative and the Fistula First Initiative recommend the use of arteriovenous fistulas (AVFs) over the use of other capsular access options. However, according to Davis Bradford and Michael Allon of the University of Alabama School of Medicine, Birmingham, clinical decision making regarding the optimal vascular access type should ... Read More »

Infection-Related Hospitalizations and 30-Day Readmissions among HD Patients

Among patients receiving in-center hemodialysis, there are significant clinical complications associated with hospitalizations for infections. That was the primary finding of a retrospective cohort study conduced recently by Lorien S. Dalrymple, MD, MPH, and colleagues. The researchers reported study results in the American Journal of Kidney Diseases [2015;65(5):754-762]. In patients receiving hemodialysis, infection accounts for nearly one-fourth of hospitalizations, according ... Read More »

Cost-Effectiveness of Biocompatible Solutions in Peritoneal Dialysis

For patients receiving peritoneal dialysis (PD) therapy, biocompatible solution may offer a cost-effective alternative to standard solutions. That was the primary finding of a secondary economic evaluation of a randomized controlled trial conducted recently by Kirsten Howard, PhD, and colleagues. The researchers reported their results in the American Journal of Kidney Diseases [2015;65(5):773-779]. PD is a home-based model that more ... Read More »

CKD Stage Has Impact on Hospital Costs in Moderate-to-Severe CKD

Renal replacement therapy (RRT), major vascular events, and deaths, both vascular and non-vascular, are the key determinants of costs of hospital care in the United Kingdom for patients with moderate-to-severe chronic kidney disease (CKD). That was the primary finding of a secondary analysis of data from the SHARP (Study of Heart and Renal Protection) trial conducted recently by Seamus Kent, ... Read More »

ATP_CD4 as Prognosis Indicator in Sepsis-Associated AKI

According to researchers, it is difficult, if not impossible, to predict renal and general outcomes in acute kidney injury (AKI). Further, current diagnostic markers do not allow for early diagnosis of AKI, contributing to the disease’s poor prognosis. Daniel Patschan, MD, and colleagues conducted a prospective study designed to investigate CD4+ ATP (ATP_CD4) in sepsis-associated AKI. They reported study results ... Read More »

Aortic Stiffness Not a Factor in BP Control in Hemodialysis Patients

Aortic pulse wave velocity (PWV) is a marker of long-term structural alterations in the arterial wall reflecting the arteriosclerotic process. In hypertensive dialysis patients, aortic PWV is not a predictor of treatment-induced changes in ambulatory blood pressure, indicating that hypertension can be successfully controlled regardless of aortic stiffness. Those were the primary findings of a post hoc analysis of data ... Read More »