Comparing Estimated GFR Equations in Pediatric Transplant Patients

There is increasing interest in alternative methods to calculate glomerular filtration rate (GFR), such as the use of cystatin C, which was introduced as a marker for glomerular filtration in 1985. Cystatin C is a 13.3-kDa molecule that is produced by all nucleated cells, freely filtered in the glomerulus, and subsequently re-absorbed and degraded in the proximal tubule. The production ... Read More »

Sirolimus Lowers Risk for Skin Cancer in Transplant Recipients

Recipients of solid-organ transplants are at increased risk of skin cancer compared with the risk among the general population. Increases in incidence of cancer formation of 3- to 4-fold have been reported in the solid-organ transplant population. The more common cancer in solid-organ transplant recipients (OTRs) is nonmelanoma skin cancer (predominately cutaneous squamous cell carcinoma [CSCC]), followed by posttransplant lymphoproliferative ... Read More »

Reporting Quality of Life Outcomes in Trials of Immunosuppressive Drugs

Patient-centered care is informed by quality of life outcomes of clinical trials, particularly when treatments have varying side effects and adverse outcomes that affect patient experience and well being. Patients who have undergone kidney transplantation, the treatment of choice for end-stage renal disease, must be adherent to lifelong immunosuppression to maintain optimal transplant function. Immunosuppression drugs have varying side-effect profiles, ... Read More »

September 2016: Abstract Roundup

Acute Kidney Injury Risk of AKI in Children in the ICU Pediatric Critical Care Medicine. Doi:10.1097/PCC.0000000000000859 Morgan B. Slater, PhD, and colleagues recently conducted a cohort study of critically ill children. The study was designed to estimate the frequency of acute kidney injury (AKI) in children in the intensive care unit (ICU) and examine the factors both prior to and ... Read More »

July/August 2016: News Briefs

Clinical Trial Alert CorMedix is currently conducting phase 3 clinical trials at sites around the United States for Neutrolin®, a catheter lock solution for the prevention of catheter-related bloodstream infections and maintenance of catheter patency in tunneled, cuffed, central venous catheters used for vascular access in patients undergoing hemodialysis. Neutrolin is a formulation of taurolidine 1.35%, citrate 3.5%, and heparin ... Read More »

Risk Factors for Cognitive Dysfunction in Children and Young Adults

Adults and children with chronic kidney disease (CKD) may experience cognitive dysfunction across a range of cognitive functions such as IQ, verbal and visual skills, memory, attention, processing speed, and executive function. These deficits may be attributed to psychosocial factors such as depression, stress, or school absences due to medical treatments, or to general malnutrition. Cognitive dysfunction has also been ... Read More »

Hemodialysis Patients with Ocular Disorders at Increased Risk for Mortality and Atherosclerotic Events

Patients on hemodialysis may develop ocular disorders that can be due to underlying diseases, a poor uremic status, iatrogenic complications of hemodialysis, poor fluid hemostasis, or elevated calcium-phosphate products. Common ocular disorders in this population include increased intraocular pressure, scratchy red eyes, band keratopathy, and retinal ischemia. Retinal ischemia may lead to serious deterioration of vision and a reduction in ... Read More »

Low-Sodium Peritoneal Dialysis Solutions in Patients with Hypertension

The renal replacement therapy peritoneal dialysis should ensure solute clearance, peritoneal ultrafiltration, and the physiologic homeostasis of electrolytes; the therapy should also maintain acid-base balance. Dialysis dose, expressed as Kt/V, is the accepted definition of adequate dialysis. Other clinical outcomes of interest include effective hypertension control, which helps prevent cardiovascular complications, the most common causes of death among dialysis patients. ... Read More »

Insurance Status and Mortality among Patients with Albuminuria

Previous studies have established the association between uninsurance and mortality in the general population. Researchers, led by Milda R. Saunders, MD, MPH, recently conducted a study designed to assess the association on health insurance status with morality among working-age individuals with albuminuria. The study utilized data from the Third National Health and Nutrition Examination Survey, 1988-1994 (NHANES III). Study results ... Read More »

Identifying Patients at High Risk for Discontinuation of Home Hemodialysis

There are approximately 450,000 people in the United States who are being treated for end-stage renal disease (ESRD) with maintenance dialysis; about 90% of those individuals receive hemodialysis three times a week. The mortality rate among dialysis patients is 6.1 to 7.8 times higher than that among age-matched Medicare beneficiaries; the hospitalization rate is 1.73 admissions per patient per year; ... Read More »