Cluster Analysis Useful in Evaluating Claims Data Set

Chronic kidney disease (CKD) affects approximately 600,000 to 900,000 individuals in the United States. Management of CKD is clinically complicated and has become an urgent health concern and an epidemic worldwide. Even with adequate therapy, CKD progresses to end-stage renal disease, necessitating use of renal replacement therapy (RRT) (eg, hemodialysis or peritoneal dialysis). Hemodialysis, the more common and costly of ... Read More »

Risk of Cardiovascular Disease Increased with Higher Urinary Sodium Excretion

Approximately 11% of the general population in the United States is affected by chronic kidney disease (CKD), which is associated with increased risk of end-stage renal disease, cardiovascular disease (CVD), and all-cause mortality. More than one in three adults in the United States has CKD, the leading cause of death in the United States. Compared with individuals with normal kidney ... Read More »

Perioperative Levosimendan Reduces AKI Incidence in Cardiac Surgery Patients

In patients undergoing cardiac surgery, perioperative administration of levosimendan may reduce complications. That was among the findings of a random-effect meta-analysis conducted recently by Chenghui Zhou, MD, PhD, and colleagues. The researchers reported results of the analysis in the American Journal of Kidney Diseases [2-16;67(3):408-416]. Acute kidney injury (AKI) occurs in up to 45% of patients following cardiac surgery. It ... Read More »

Serelaxin Reduced Cardiovascular Mortality in Patients with Renal Dysfunction

Patients with acute heart failure frequently experience renal dysfunction and worsening of renal function; both conditions are associated with longer hospital stays and greater risk of rehospitalization and mortality. The RELAX-AHF (Relaxin in Acute Heart Failure) trial was conducted to examine the effects of serelaxin, a novel recombinant of the naturally occurring human relaxin-2 vasoactive peptide. The agent was administered ... Read More »

Differences in Initial Vascular Access by Glomerulonephritis Subtypes

In patients with end-stage renal disease (ESRD) undergoing hemodialysis, vascular access is an important determinant of health outcomes. Patients using an arteriovenous fistula (AVF) have significantly lower mortality and fewer hospitalizations and cardiovascular events than patients with a central venous catheter (CVC); patients using arteriovenous grafts (AVGs) generally have outcomes that fall between those of patients using AVF or CVC ... Read More »

Comparing Estimated GFR Equations in Pediatric Transplant Patients

There is increasing interest in alternative methods to calculate glomerular filtration rate (GFR), such as the use of cystatin C, which was introduced as a marker for glomerular filtration in 1985. Cystatin C is a 13.3-kDa molecule that is produced by all nucleated cells, freely filtered in the glomerulus, and subsequently re-absorbed and degraded in the proximal tubule. The production ... Read More »

Sirolimus Lowers Risk for Skin Cancer in Transplant Recipients

Recipients of solid-organ transplants are at increased risk of skin cancer compared with the risk among the general population. Increases in incidence of cancer formation of 3- to 4-fold have been reported in the solid-organ transplant population. The more common cancer in solid-organ transplant recipients (OTRs) is nonmelanoma skin cancer (predominately cutaneous squamous cell carcinoma [CSCC]), followed by posttransplant lymphoproliferative ... Read More »

Reporting Quality of Life Outcomes in Trials of Immunosuppressive Drugs

Patient-centered care is informed by quality of life outcomes of clinical trials, particularly when treatments have varying side effects and adverse outcomes that affect patient experience and well being. Patients who have undergone kidney transplantation, the treatment of choice for end-stage renal disease, must be adherent to lifelong immunosuppression to maintain optimal transplant function. Immunosuppression drugs have varying side-effect profiles, ... Read More »

September 2016: Abstract Roundup

Acute Kidney Injury Risk of AKI in Children in the ICU Pediatric Critical Care Medicine. Doi:10.1097/PCC.0000000000000859 Morgan B. Slater, PhD, and colleagues recently conducted a cohort study of critically ill children. The study was designed to estimate the frequency of acute kidney injury (AKI) in children in the intensive care unit (ICU) and examine the factors both prior to and ... Read More »

July/August 2016: News Briefs

Clinical Trial Alert CorMedix is currently conducting phase 3 clinical trials at sites around the United States for Neutrolin®, a catheter lock solution for the prevention of catheter-related bloodstream infections and maintenance of catheter patency in tunneled, cuffed, central venous catheters used for vascular access in patients undergoing hemodialysis. Neutrolin is a formulation of taurolidine 1.35%, citrate 3.5%, and heparin ... Read More »