ESRD Risk Higher in Recurrent Kidney Stone Formers than in Incident Kidney Stone Formers

It is thought that patients who form kidney stones are at increased risk for cardiovascular events, chronic kidney disease (CKD), and end-stage renal disease (ESRD); if that increased risk is accurate, it may also be expected that kidney stone formers are at increased risk for mortality. Those patients also have an increased comorbidity burden, including dyslipidemia, hypertension, diabetes, and metabolic ... Read More »

Missed Hemodialysis Treatments Associated with Increased Risk of Mortality

Hemodialysis therapy is typically provided three times a week for several hours for each treatment, creating considerable burdens on patients. There are wide variations in the extent to which those burdens affect patients’ quality of life; there may be negative effects on patient adherence to their treatment regimens among those who find their regimens particularly burdensome. One form of nonadherence ... Read More »

Levels of Trace Elements in Pediatric Patients with End-Stage Renal Disease

Nutritional disturbances are often seen in children with end-stage renal disease (ESRD), potentially affecting their growth and development. Some nutritional elements and electrolytes are part of routine monitoring in patients with chronic kidney disease (CKD) and in pediatric dialysis patients; however, there are no examinations of levels of trace elements until after significant complications and/or problems arise. Pediatric patients on ... Read More »

Antihypertensive Drug Effects on Surrogate End Points for ESRD: A Systematic Review

Chronic kidney disease (CKD) affects 10% to 15% of the population and is associated with progression to end-stage renal disease (ESRD) and premature death. Treatment aimed at lowering blood pressure is used to prevent kidney function failure and ESRD; however, ESRD is a less frequent outcome of CKD compared with cardiovascular disease and death and requires trials with large patient ... Read More »

Low eGFR Associated with Hospital-Acquired Infections Following Major Surgery

The US Department of Health and Human Services and the European Centre for Disease Prevention and Control have set prevention of hospital-acquired infections as one of their highest priorities. Hospital-acquired infections are associated with increased risk for mortality and morbidity, prolonged hospital length-of-stay, and increases in healthcare costs. Many hospital-acquired infections are preventable, creating the need to focus interventions on ... Read More »

Examining Short-Term Within-Person Variability in Clinical Markers of Kidney Function

Chronic kidney disease (CKD) is defined by abnormalities in glomerular filtration rate (GFR) and/or albuminuria; CKD affects approximately 10% of the US population. Endogenous plasma or serum filtration markers, most commonly creatinine, are used to estimate GFR; albuminuria is quantified by measuring urinary albumin concentration (UAC) or urinary albumin-creatinine ratio (UACR). There are well established reference ranges for estimated GFR ... Read More »

Limiting Interdialytic Weight Gain in Patients on Hemodialysis

Many patients on chronic hemodialysis therapy exceed the recommended values of interdialytic weight gain (IDWG) of 4.0% to 4.5% of dry weight; some have IDWG of 10% to 20%. There are associations between higher IDWG and increased risk of all-cause and cardiovascular death. IDWG has also been shown to be a risk factor for increased morbidity, including ventricular hypertrophy and ... Read More »

Dietary Implications of Renal Impairment and Levels of Toxic Metabolites

According to Michael Pignanelli, BMSc, and colleagues, variations in atherosclerosis burden can only be partly explained by traditional risk factors for coronary heart disease (CHD), and genetic variants may account for only 10.6% of heritability of CHD. Following treatment with usual care for traditional risk factors, the risk of cardiovascular events remains approximately 40%. There is an independent association between ... Read More »

Burden of Chronic Kidney Disease Increased and Varied by State from 2002 to 2016

Over the past 15 years, the United States has seen demographic, social, and epidemiologic changes; there have also been substantial increases in measures of sociodemographic development and exposure to risk factors for chronic kidney disease (CKD) over the same period. To date, there has not been a detailed quantitative analysis of the change in burden of CKD. Benjamin Bowe, MPH, ... Read More »