Angiogenesis Marker Concentrations and Acute Kidney Injury after Cardiac Surgery

Acute kidney injury (AKI) occurs in 5% to 10% of all hospital admissions and in up to 30% of hospital admissions for cardiac surgery. There are independent associations between longer duration of AKI and greater severity of AKI and increased mortality. After the initial injury, recovery or progression of kidney disease is guided by biologic processes; some processes lead to ... Read More »

Coronary Artery Calcification and Serum Calcification Propensity in Patients with CKD

The leading cause of death among patients with chronic kidney disease (CKD) is cardiovascular disease. Patients with CKD may develop vascular calcification, one mechanism that increases the cardiovascular disease risk in that patient population. Medial calcification is associated with increased arterial stiffness and heart failure; patients with CKD are also at risk for intimal calcification, indicative of atherosclerosis. The coronary ... Read More »

Relationship of Dietary Fiber Intake to Inflammation and Oxidative Stress in Patients on Hemodialysis

In western countries, there has been a decrease in total dietary fiber (TDF) intake in recent years. Increasing the consumption of foods rich in fiber is recommended in many healthy eating guidelines from public health communities. In patients receiving maintenance hemodialysis, dietary restrictions of potassium and phosphorus and the incidence of malnutrition are the primary contributors to decreased consumption of ... Read More »

IDEAL Trial Results and Changes in Dialysis Initiation Timing in Canada

The optimal time to initiate dialysis for the treatment of kidney failure remains uncertain. Renal recovery is rare following dialysis initiation and patients receiving dialysis treatments are at high risk for morbidity and mortality and a diminishing quality of life. Further, early initiation of dialysis increases healthcare costs and may not provide optimal value from a health system perspective. Results ... Read More »

Hydroxychloroquine plus RAAS Inhibition Reduced Proteinuria in Patients with IgAN

Worldwide, the most prevalent form of primary glomerular disease is immunoglobulin A (IgA) nephropathy (IgAN). The disease usually progresses from chronic slowly progressive kidney injury; however, as many as 30% of patients will progress to end-stage kidney failure. Proteinuria is strongly associated with decline in kidney failure; despite optimized renin-angiotensin-aldosterone system (RAAS) inhibitor therapy, patients with IgAN and persistent proteinuria ... Read More »

Protein Loss in Peritoneal Dialysis Patients Underestimated in Current Equations

The risk of losing muscle mass is elevated in patients with chronic kidney disease (CKD) due, in part, to episodes of metabolic acidosis during disease progression, low-protein diets aiming to slow CKD progression, bone and mineral disorders, and background inflammation. Current clinical guidelines call for regular assessment of dietary protein intake; nutritional targets are designed to reduce muscle breakdown and ... Read More »

No Change in Frequency of Hypotensive Events in Patients Receiving Meals during Hemodialysis

End-stage renal disease (ESRD) poses a major public health concern in the United States; the standard treatment for ESRD is hemodialysis. Patients receiving maintenance hemodialysis have dietary needs and restrictions, including requirements for increased protein (1.2 g/kg/day) and energy (30-35 kcal/kg/day) intake and restricted intake of phosphorus, sodium, potassium, and/or fluid. The restrictions add to the difficulty of meeting the ... Read More »

Association of Periodontitis with Decreased Kidney Function Over Time

Chronic periodontitis is a local inflammatory condition that affects the tooth-supporting tissues. There is an association between periodontitis and higher levels of locally produced proinflammatory markers, contributing to low-grade systemic inflammation. It is possible that periodontitis contributes to decline in kidney function because: (1) periodontitis contributes to overall systemic inflammatory burden, possibly triggering kidney function decline; and (2) periodontal bacteria ... Read More »

Association of Plasma Metabolites and Lipids with Kidney Function in Early ADPKD

Autosomal dominant polycystic kidney disease (ADPKD), characterized by gradual enlargement of numerous cysts in the kidneys over decades, affects one in 1000 individuals. The disease process begins before loss of estimated glomerular filtration rate (eGFR) occurs. The most common genetic cause of ADPKD are mutations in polycystin 1 (PKD1, ~75%); the second most common are mutations in polycystin 2 (PKD2, ... Read More »