Weight Loss in Children and Adolescents with CKD Occurs with Decrease in eGFR

Children with chronic kidney disease (CKD), including end-stage renal disease (ESRD), are at risk for weight loss. Results of prior cross-sectional studies in adults have suggested that weight loss begins to occur at an estimated glomerular filtration rate (eGFR) of 40 mL/min/1.73 m2. However, there are few available data for longitudinal assessments of the timing or degree of weight loss ... Read More »

Center-Level Characteristics and Variations in Peritoneal Dialysis Outcomes

One of the most common reasons for discontinuation of peritoneal dialysis therapy is peritonitis. A significant proportion of patients receiving peritoneal dialysis who develop peritonitis experience serious adverse outcomes, including hospitalization, relapsed or recurrent peritonitis, removal of the peritoneal dialysis catheter, permanent transfer to hemodialysis therapy, and/or death. Studies have documented marked variation in peritonitis rates and technique survival across ... Read More »

Developing and Validating New Models to Estimate Lean Body Mass in Patients with CKD

Protein-energy wasting (PEW), a condition associated with adverse outcomes due to cardiac comorbidity and inflammation, is a common complication in patients with CKD. Patients undergoing dialysis experience PEW most often, but PEW is also seen in non–dialysis-dependent CKD patients. As renal function declines, protein catabolism can be gradually aggravated via various complex mechanisms and may become apparent in nutritional indices ... Read More »

Mineral Handling in Hemodialysis Patients

There is an association between chronic kidney disease (CKD) and an increased risk of cardiovascular morbidity and mortality. In patients with CKD, increased circulating concentrations of phosphate and fibroblast growth factor-23 (FGF23) are highly predictive of cardiovascular disease. In order to maintain long-term calcium and phosphate balance, in healthy individuals an ingested mineral load is acutely buffered by a rapidly ... Read More »

Protein-Energy Wasting More Prevalent in Women and Increases with Age

Approximately one-third of older adults in Europe are classified as malnourished upon admission to the hospital. Many patients also have chronic kidney disease (CKD), making nutritional problems more complex compared with those without CKD. Protein-energy easting (PEW) is defined as inadequate nutrient intake, in combination with other factors including inflammation, acidosis, and endocrine disorders that lead to increased net breakdown ... Read More »

Post Hoc Analysis of HALT-PKD Data Examines Patterns of Kidney Function Decline

An estimated one in 400 to 1000 individuals in the United States and more than 12 million worldwide are affected by autosomal dominant polycystic kidney disease (ADPKD). The predominant causative genes are PKD1 on chromosome 16 and PKD2 on chromosome 4. For patients with PKD1 genotype, mean age at onset of end-stage renal disease (ESRD) is 56 years; for patients ... Read More »

Study Protocol: Outcomes in Dialysis Patients with Aortic Stenosis

Worldwide, the number of patients receiving maintenance dialysis is increasing. Diabetic nephropathy and hypertensive kidney disease account for many of these patients. In addition, chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease, which leads to difficulty with dialysis therapy. While coronary heart disease is typical among patients with cardiovascular disease, patients on dialysis are increasingly being ... Read More »

Time Trends in ESRD in France and Forecast to the Year 2030

Due to the increasing number of patients in France with end-stage renal disease (ESRD) requiring renal replacement therapy (RRT), the management of ESRD is a top public health priority. As of December 31, 2015, there were 82,295 patients receiving RRT: 54% of those were on dialysis and 46% were living with a functional renal transplant.  Overall, the crude prevalence was ... Read More »

“New Deal” for Kidney Care for US Veterans Outlined

Results of recent analyses have shown that veterans receiving care from the Department of Veterans Affairs (VA) healthcare system are experiencing improvements in kidney health outcomes. Susan T. Crowley, MD, and Katherine Murphy, MHSA, employees of the Veterans Health Administration, suggest that “scrutiny of the agency’s current care model may identify population health initiatives associated with improved outcomes that could ... Read More »

Study Finds Antibiotic Use Linked to Kidney Stone Risk

Use of certain oral antibiotics may be linked to the growing incidence of kidney stone formation, according to a study recently published in the Journal of the American Society of Nephrology. Conducted by researchers at the Children’s Hospital of Philadelphia (CHOP), this study found that younger patients who were exposed to antibiotics were at the highest risk of developing kidney ... Read More »