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Pediatric CKD Progression Associated with Baseline Proteinuria

Clinical Journal of the American Society of Nephrology. 2015. 10(4):571-577. In children with nonglomerular chronic kidney disease (CKD), baseline proteinuria and systolic blood pressure levels are independently associated with progression of CKD. That was the conclusion of a study conducted recently by Sahar A. Fathallah-Shaykh, MD, and colleagues. Most cases of CKD in children are causes by congenital anomalies of ... Read More »

Risk of CKD in MHO Phenotype Patients

Clinical Journal of the American Society of Nephrology. 2015;10(4):578-583. In a recent study conducted by Yoshitaka Hashimoto, MD, and colleagues, there was no association between metabolically healthy obesity (MHO) and increased risk of incident chronic kidney disease (CKD). MHO is an obesity phenotype that appears to people from the metabolic complications of obesity. Any association between MHO phenotype and incident ... Read More »

Timing of Arteriovenous Fistula Placement in Elderly Patients

Journal of the American Society of Nephrology. 2015;26(2):448-456. The preferred vascular access for hemodialysis is arteriovenous fistula (AVF). However, some AVFs fail before the onset of dialysis. Tammy Hod, MD, and colleagues recently conducted a study to determine the optimal time for placement of an AVF in elderly hemodialysis patients. They identified 17,511 incident dialysis patients ≥67 years of age ... Read More »

Vitamin K Insufficiency Associated with Increased Risk of Mortality

There is an independent association between vitamin K insufficiency and increased risk of mortality among stable kidney transplant recipients. That was the primary finding of an observational study conducted recently by Charlotte A. Keyzer, MD, and colleagues. Study results were reported in the American Journal of Kidney Diseases [2015;65(3):474-483]. The prognosis of patients with end-stage renal disease is substantially improved ... Read More »

Monotherapy with ACE Inhibitor and Blood pressure Control in Patients with ADPKD

In most patients with autosomal dominant polycystic kidney disease (ADPKD) and stage 3 chronic kidney disease, monotherapy with an angiotensin-converting enzyme (ACE) inhibitor was associated with blood-pressure control in a trial conducted recently by Vicente E. Torres, MD, PhD, and colleagues. The researchers reported the findings online in the New England Journal of Medicine [2014. doi:10.1056/NEJMoal402686]. In patients with ADPKD, ... Read More »

Executive Function Associated with Increased Mortality Risk in Hemodialysis Patients

Worse cognitive function, particularly worse executive function, is associated with a higher risk of mortality in patients on maintenance hemodialysis. This relationship may be partially associated with the burden of cerebrovascular disease. Those were the primary findings of a study conducted recently by David A. Drew, MD, and colleagues. The researchers reported study results in the American Journal of Kidney ... Read More »

Peritoneal Dialysis Patients Have Low Mortality but High Morbidity

In a study reported in the American Journal of Kidney Diseases [2014;64(5):761-769], Joseph Pulliam, MD, and colleagues reported that despite low mortality rates among patients initiating renal replacement therapy with peritoneal dialysis (PD), incident PD patients had high morbidity, particularly within the first 3 to 6 months. Compared with other countries, the prevalence of PD therapy in the United States ... Read More »

Vascular Access Type Associated with Inflammation

The CHOICE (Choices for Healthy Outcomes in Caring for ESRD [end-stage renal disease]) study was designed to examine the role of access on serial levels of inflammatory markers. Results of the study, reported in the American Journal of Kidney Diseases, support recommendations for the early removal or avoidance of central venous catheter (CVC) placement. Tanushree Banerjee, PhD, and colleagues conducted ... Read More »

ESA Use Before and After TREAT

In 1989, the US FDA approved erythropoiesis-stimulating agents (ESAs) such as epoetin alfa (erythropoietin) to treat anemia associated with kidney disease. It was not until October 2009 that the first placebo-controlled ESA trail in patients with chronic kidney disease (CKD) with hard outcomes was published, according to Mae Thamer, PhD, and colleagues in an article in the American Journal of ... Read More »

NKF Holds Spring Clinical Meetings

The National Kidney Foundation held its 2015 Spring Clinical Meetings in Dallas, Texas, March 25-29. The meeting was an opportunity for renal health care providers to learn new developments related to all aspects of nephrology. It was designed for kidney doctors in the private sector and academia, fellows and residents with a special interest in kidney disease, general internists, pharmacists, ... Read More »