Focus on Transplantation

Medication Adherence among Teen and Young Adult Transplant Recipients

Chicago Adherence to immunosuppressive medication in adolescent and young adult kidney transplant recipients is poorer than in children. However, there are few data on whether adherence varies between males and females, or by age, in adolescents and young adults. Julie Boucquemont, MD, and Bethany J. Foster, MD, conducted an analysis of data from the 3-month run-in period (with no intervention) ... Read More »

Nonwhite Organ Transplant Recipients at High Risk for Skin Cancer

In 2015, approximately 13,000 nonwhite (black, Asian, Hispanic, Pacific Islander) individuals received an organ transplant; this population has a higher incidence of new skin cancers compared with comparable nontransplant recipients. This risk increases over time with continued exposure to immunosuppression regimens. Squamous cell carcinoma (SCC) is increased 65-fold, basal cell carcinoma (BCC) is increased 10-fold, and melanoma is increased 3-fold ... Read More »

Combined Liver-Kidney Transplantation in Children with ARPKD

The most common cystic kidney disease in the pediatric population is autosomal recessive polycystic kidney disease (ARPKD); it occurs in one of 20,000 live births, and is associated with mutations in one gene, polycystic kidney and hepatic disease 1 (PKHD1), on chromosome 6p12. ARPKD is a significant cause of kidney- and liver-related morbidity and mortality in children. The mortality rate ... Read More »