Focus on Transplantation

Evaluating Intrarenal Vasculature after Renal Transplantation with Doppler Ultrasound

Chicago—Doppler ultrasound, which facilitates the global evaluation of intrarenal vasculature, is a valuable, noninvasive tool for the diagnosis of complications in renal transplantation. Amir Shabaka, MD, and colleagues recently conducted a retrospective study designed to examine the evolution of renal graft hemodynamics in the immediate postoperative period following transplantation as well as early periods post-transplant. The researchers reported study results ... Read More »

Body Composition and Frailty after Transplant

Chicago—Recent studies have suggested that frailty is a risk factor for poor outcomes following kidney transplantation. Patients with preoperative fraility are at increased risk for early hospital readmission, delayed graft function, and mortality, regardless of their age. One component of frailty after kidney transplantation is weight loss; however, changes in lean and fat mass are not fully accounted for by ... Read More »

Long-Term Survival in Transplant Recipients Undergoing Heart Surgery

Chicago Researchers at a university hospital in Norway evaluated results of open heart surgery in kidney transplant recipients from 1989 to 2015. Bartlomiei J. Witczak, MD, and colleagues reported results of the analysis during a poster session at Kidney Week 2016 in a poster titled Outcomes after Open Heart Surgery in Kidney Transplant Recipients and Matched Controls. During the study ... Read More »

Employed Patients More Likely to Have Transplant List Status

Chicago The optimal long-term treatment option for patients with end-stage renal disease (ESRD) who are on hemodialysis is often kidney transplantation. Qualifications for placement on the active transplant list include patient motivation and engagement with the process. Researchers, led by Deborah S. Evans, recently conducted an analysis to assess transplant status among employed versus unemployed ESRD patients. Results were reported ... Read More »

Statin Use Suboptimal among Post-Transplant Veterans

Chicago Treatment guidelines from Kidney Disease, Improving Global Outcomes (KDIGO) and Kidney Disease Outcomes Quality Initiative (KDOQI) recommend statin medications for kidney transplant recipients. However, data from some empirical studies indicate that statins are underutilized on that patient population. Arouna Senthilkumar, MD, and colleagues recently conducted a retrospective analysis of data from the US Department of Veterans Affairs Healthcare System ... Read More »

Medication Adherence among Teen and Young Adult Transplant Recipients

Chicago Adherence to immunosuppressive medication in adolescent and young adult kidney transplant recipients is poorer than in children. However, there are few data on whether adherence varies between males and females, or by age, in adolescents and young adults. Julie Boucquemont, MD, and Bethany J. Foster, MD, conducted an analysis of data from the 3-month run-in period (with no intervention) ... Read More »

Nonwhite Organ Transplant Recipients at High Risk for Skin Cancer

In 2015, approximately 13,000 nonwhite (black, Asian, Hispanic, Pacific Islander) individuals received an organ transplant; this population has a higher incidence of new skin cancers compared with comparable nontransplant recipients. This risk increases over time with continued exposure to immunosuppression regimens. Squamous cell carcinoma (SCC) is increased 65-fold, basal cell carcinoma (BCC) is increased 10-fold, and melanoma is increased 3-fold ... Read More »

Combined Liver-Kidney Transplantation in Children with ARPKD

The most common cystic kidney disease in the pediatric population is autosomal recessive polycystic kidney disease (ARPKD); it occurs in one of 20,000 live births, and is associated with mutations in one gene, polycystic kidney and hepatic disease 1 (PKHD1), on chromosome 6p12. ARPKD is a significant cause of kidney- and liver-related morbidity and mortality in children. The mortality rate ... Read More »