Levofloxacin Does Not Prevent BK Virus After Transplantation

A 3-month course of levofloxacin begun soon after transplantation did not prevent BK viruria among kidney transplant recipients. That was the primary finding of a trial conducted recently by Greg A Knoll, MD, and colleagues, and reported online in the Journal of the American Medical Association [doi:10.1001/jama.2014.14721]. Due in part to the development of potent immunosuppressant medication, BK virus infection ... Read More »

Association of Dialysis modality and Likelihood of Kidney Transplant

Dallas—Of patients who initiated home dialysis within 6 months of a diagnosis of end-stage renal disease (ESRD), those who began daily home hemodialysis (DHHD) were significantly more likely to receive a kidney transplant than a matched cohort of patients who began peritoneal dialysis (PD). Likewise, patients who began daily home hemodialysis within 6 months of ESRD diagnosis were significantly more ... Read More »

Proton Pump Inhibitors versus H2 Blockers and Risk of Hypomagnesemia

Philadelphia—At many transplant centers, the use of proton pump inhibitors (PPIs) has replaced the use of H2 receptor blockers (H2B) for gastrointestinal prophylaxis, despite a lack of evidence for superior efficacy of PPIs over H2Bs. According to researchers, although PPIs are generally safe medications, their use has been associated with hypomagnesemia due to impaired gastrointestinal absorption. Mohamad Alhosaini, MD, and ... Read More »

Vitamin K Insufficiency Associated with Increased Risk of Mortality

There is an independent association between vitamin K insufficiency and increased risk of mortality among stable kidney transplant recipients. That was the primary finding of an observational study conducted recently by Charlotte A. Keyzer, MD, and colleagues. Study results were reported in the American Journal of Kidney Diseases [2015;65(3):474-483]. The prognosis of patients with end-stage renal disease is substantially improved ... Read More »

Induction with Alemtuzumab Has Low Incidence of BK Nephropathy

Philadelphia—Kidney injury and graft failure are increasingly being associated with BK nephropathy. Current literature suggests an association between high immunosuppression dose and increased incidence of BK viruria, viremia, and nephropathy. According to Pradeep Vaitla, MD, and colleagues, most transplant centers in the United States use antibody induction with rabbit antihymocyte globulin or alemtuzumab to minimize maintenance immunosuppression. The researchers recently ... Read More »

Focus on Transplantation

There are few data from randomized clinical trials on nutrition interventions following kidney transplantation. Further, there is a lack of evidence for effective interventions to prevent weight gain after transplantation. Kristin J. Ryan and colleagues are currently conducting the INTENT (Intensive Nutrition Interventions on Weight gain after Kidney Transplantation) trial; they reported on the protocol of the trial in BMC ... Read More »

Attitudes toward Organ Donation among Canadian First Nations People

Compared with the general population in Canada, willingness to donate organs for transplantation was lower in First Nation participants in a recent study conducted by Sara N. Davison, MD, and colleagues. That was among the findings reported in the American Journal of Kidney Diseases [2015;64(5):781-789]. There is a high demand for organ donation among aboriginal people in Canada, yet the ... Read More »

Spot Urine Sample Similar to 24-Hour Measurement as Outcome Predictor

Protein excretion can be measured using spot urine samples in kidney transplant recipients. That was the primary finding of a study conducted recently by Hari Talreja, MD, and colleagues. The researchers reported study results in the American Journal of Kidney Diseases [2014;64(6):962-968]. Total urinary albumin and protein excretion have been associated with progressive decreases in kidney function, transplant loss, and ... Read More »


NODAT and Risk of Cardiovascular-Related Mortality There is increased risk of cardiovascular complications in patients who develop new-onset diabetes after transplantation (NODAT). Further, despite the use of a steroid sparing immunosuppressive regimen, patients who develop NODAT have reduced survival. Moutzouris, MD, and colleagues at the Imperial College Renal and Transplant Centre in London, United Kingdom, recently conducted a retrospective, single-center ... Read More »

Post-Transplant Immunosuppressive AEs Scoring System Validated

Patient safety and immunosuppressive adherence post-transplant may be improved utilizing a clinician administered immunosuppressive adverse effects (AEs) scoring system that was validated in a recent study conducted by Calvin J. Meaney, PharmD, et al. Study findings were reported in BMC Nephrology [doi:10.1186/1471-2369-15-88]. Compared with chronic dialysis, renal transplantation is the preferred intervention for patients with end-stage renal disease. To prevent ... Read More »