Cover Stories

Ticagrelor versus Clopidogrel in Patients on Maintenance Hemodialysis

In patients with kidney failure receiving maintenance hemodialysis who require antiplatelet treatment, ticagrelor may result in more rapid and greater platelet inhibition than clopidogrel. That was the primary finding of a single-center, prospective, randomized, crossover study conducted recently in Seoul, Korea. Study results were reported by Kyung Hwan Jeong, MD, PhD, and colleagues in the American Journal of Kidney Diseases ... Read More »

eGFR Variability Is a Risk Factor for Progression of CKD

  There was an independent association between variability on estimated glomerular filtration rate (eGFR) and an elevated risk of progression of chronic kidney disease (CKD) among patients at high risk. That was one of the primary findings of a study reported online in BMC Nephrology [doi:10.1186/s12882-015-0025-5]. Chin-Lin Tseng, MPH, PhD, and colleagues conducted the longitudinal retrospective cohort study to evaluate ... Read More »

Determinants of Recovery of Kidney Function in Patients with AKI

“We followed the trajectory of patients who started dialysis in the hospital and then transitioned to the outpatient dialysis center.  With a new diagnosis of kidney failure, patients and providers want to know if there is any chance of kidney recovery allowing discontinuation of dialysis.  We found that the majority of patients that will recover kidney function will do so ... Read More »

Dialysis Modality Affects Exposure to Nonrenally Cleared Drugs

Exposure to intravenous midazolam is increased 6-fold in vivo in hemodialysis (HD) patients, a difference not observed in peritoneal dialysis (PD) patients. That was among the findings of a study reported in the American Journal of Kidney Diseases [2015;65(4):574-582] by Benjamin K. A. Thomson, MSc, MD, and colleagues. The median pill burden of patients with end-stage renal disease (ESRD) is ... Read More »

Serum Phosphorus Control with Lower Pill Burden

Velphoro® (sucroferric oxyhydroxide), a new, non-calcium, iron-based phosphate binder, maintained serum phosphorus control over 1 year compared with sevelamer carbonate in patients with chronic kidney disease (CKD) on maintenance dialysis. The agent was well tolerated over the long-term. Those were among the findings of a study conducted recently by Jürgen Floege, MD, and colleagues. Study results were reported in Nephrology ... Read More »

Incidence of CKD Expected to Increase over the Coming Two Decades

“The estimates of an individual’s probability of developing CKD may help raise awareness of the importance of keeping kidneys healthy. At the national level, the estimates of the rising prevalence of CKD may help policy makers plan for future health care needs and underscore the importance of developing interventions to prevent or slow kidney disease.” Thomas J. Hoerger, PhD   ... Read More »

Brain Atrophy Faster in PD Patients than in Non-Dialysis Dependent CKD Patients

There was a significantly greater decline in normalized gray matter volume (GMV) in patients receiving peritoneal dialysis (PD) compared with patients with non–dialysis-dependent chronic kidney disease (NDD-CKD), according to results of a study conducted recently by Kazuhiko Tsuruya, MD, PhD, and colleagues at the Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. The researchers reported results of the cross-sectional ... Read More »

Hemodialysis Frequency and Preservation of RKF

Twice-weekly hemodialysis for the first 6 months or longer following initiation of dialysis helped protect residual kidney function (RKF). That was one of the findings of a cohort study conducted recently by Minmin Zhang, MD, and colleagues and reported in the American Journal of Nephrology [2-14;40:140-150]. According to the researchers, RKF is increasingly being seen as an important factor influencing ... Read More »

Care for Dialysis-Dependent Patients Following Hurricane Sandy

 “So many people take emergency preparedness for granted until an emergency strikes.  This study shows that with good planning, and the help of the KCER (Kidney Community Emergency Response) coalition, providers, dialysis facilities and patients alike were able to achieve early dialysis for many patients, likely averting emergency department visits and hospitalizations—and even death.  This practice, along with other protective ... Read More »

Use and Costs of Medications to Manage CKD-MBD in Medicare Beneficiaries

“Our research highlighted the fact that Part D net costs for CKD-MBD medications increased at a faster rate than costs for all Part D medications in dialysis patients, despite relatively stable use of these medications. This suggested that, on average, acquisition prices of CKD-MBD medications were increasing faster than other drug categories. In addition, the odds of using branded more ... Read More »