Cover Stories

Measurement of Novel Filtration Markers Strong Surrogate for ESRD Risk

There is a strong association between a >30% decline in kidney function assessed using novel filtration markers and the risk of end-stage renal disease (ESRD). That was among the findings of a cohort study conducted recently by Casey M. Rebholz, PhD, MS, MPH, and colleagues. The researchers reported study findings in the American Journal of Kidney Diseases [2015;66(1):47-54]. In clinical ... Read More »

AVF Use Increased in the US after Prospective Payment System Introduction

Since the introduction of the prospective payment system, arteriovenous fistula (AVF) use has increased among prevalent hemodialysis patients in the United States, while catheter use has decreased. That was the primary finding of a prospective observational study conducted recently by Ronald L. Pisoni, PhD, MS, and colleagues. The researchers reported their findings in the American Journal of Kidney Diseases [2015;65(6):905-915]. ... Read More »

Fructose Tolerance Test in Patients with CKD versus Healthy Controls

Compared with healthy controls, baseline serum uric acid is higher in patients with chronic kidney disease (CKD) and/or metabolic syndrome, and both groups show an increase in serum uric acid after a fructose tolerance test. That was among the findings of a study designed to test the hypothesis that there might be a correlation between the change in serum acid ... Read More »

Ticagrelor versus Clopidogrel in Patients on Maintenance Hemodialysis

In patients with kidney failure receiving maintenance hemodialysis who require antiplatelet treatment, ticagrelor may result in more rapid and greater platelet inhibition than clopidogrel. That was the primary finding of a single-center, prospective, randomized, crossover study conducted recently in Seoul, Korea. Study results were reported by Kyung Hwan Jeong, MD, PhD, and colleagues in the American Journal of Kidney Diseases ... Read More »

eGFR Variability Is a Risk Factor for Progression of CKD

  There was an independent association between variability on estimated glomerular filtration rate (eGFR) and an elevated risk of progression of chronic kidney disease (CKD) among patients at high risk. That was one of the primary findings of a study reported online in BMC Nephrology [doi:10.1186/s12882-015-0025-5]. Chin-Lin Tseng, MPH, PhD, and colleagues conducted the longitudinal retrospective cohort study to evaluate ... Read More »

Determinants of Recovery of Kidney Function in Patients with AKI

“We followed the trajectory of patients who started dialysis in the hospital and then transitioned to the outpatient dialysis center.  With a new diagnosis of kidney failure, patients and providers want to know if there is any chance of kidney recovery allowing discontinuation of dialysis.  We found that the majority of patients that will recover kidney function will do so ... Read More »

Dialysis Modality Affects Exposure to Nonrenally Cleared Drugs

Exposure to intravenous midazolam is increased 6-fold in vivo in hemodialysis (HD) patients, a difference not observed in peritoneal dialysis (PD) patients. That was among the findings of a study reported in the American Journal of Kidney Diseases [2015;65(4):574-582] by Benjamin K. A. Thomson, MSc, MD, and colleagues. The median pill burden of patients with end-stage renal disease (ESRD) is ... Read More »

Serum Phosphorus Control with Lower Pill Burden

Velphoro® (sucroferric oxyhydroxide), a new, non-calcium, iron-based phosphate binder, maintained serum phosphorus control over 1 year compared with sevelamer carbonate in patients with chronic kidney disease (CKD) on maintenance dialysis. The agent was well tolerated over the long-term. Those were among the findings of a study conducted recently by Jürgen Floege, MD, and colleagues. Study results were reported in Nephrology ... Read More »

Incidence of CKD Expected to Increase over the Coming Two Decades

“The estimates of an individual’s probability of developing CKD may help raise awareness of the importance of keeping kidneys healthy. At the national level, the estimates of the rising prevalence of CKD may help policy makers plan for future health care needs and underscore the importance of developing interventions to prevent or slow kidney disease.” Thomas J. Hoerger, PhD   ... Read More »

Brain Atrophy Faster in PD Patients than in Non-Dialysis Dependent CKD Patients

There was a significantly greater decline in normalized gray matter volume (GMV) in patients receiving peritoneal dialysis (PD) compared with patients with non–dialysis-dependent chronic kidney disease (NDD-CKD), according to results of a study conducted recently by Kazuhiko Tsuruya, MD, PhD, and colleagues at the Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. The researchers reported results of the cross-sectional ... Read More »