Cover Stories

Use of Proton Pump Inhibitors Associated with Increased Risk of Hypomagnesemia in General Population

In the general population, the use proton pump inhibitors is associated with hypomagnesemia, and prolonged use of a PPI with concomitant loop diuretic use are associated with a stronger increase in risk. Those were two findings of a cross-sectional analysis conducted recently by Brenda C. T. Kieboom, MD, and colleagues. The researchers reported results of the prospective cohort study in ... Read More »

Race and Ethnicity Affect Associations Between Kidney Function and Cardiovascular Events

There was a difference in the patterns of association between estimated glomerular filtration rate (eGFR) and cardiovascular risk in postmenopausal non-Hispanic white women and African American women. That was the primary finding of a prospective cohort study conducted by Cristina M. Arce, MD, MSc, and colleagues. The researchers reported study findings in the American Journal of Kidney Diseases [2016;67(2):198-208]. More ... Read More »

PTH Has Value in Predicting Low Hemoglobin Level in Non-Dialysis CKD Patients

In patients on maintenance dialysis with severe hyperparathyroidism, studies have demonstrated an association between parathyroid hormone (PTH) and anemia. However, it remains unclear whether there is an association between PTH and hemoglobin in patients with chronic kidney disease not on dialysis. Domenico Russo, MD, Luigi Morrone, MD, and colleagues recently conducted a retrospective observational cohort analysis designed to assess the ... Read More »

Mycophenolate Mofetil Trial in Patients with IgA Nephropathy Ended Early

Worldwide, the most common type of idiopathic glomerulonephritis is immunoglobulin A nephropathy (IgAN), creating a need for effective strategies for the treatment of patients with this condition to prevent kidney function decline. In some patient populations, effective treatments include corticosteroids, angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers, and omega-3 fatty acids. Previous studies have demonstrated varying results of treatment with ... Read More »

Researchers Test New Methods to Estimate Total Kidney Volume in Patients with ADPKD

The formation and growth of numerous cysts in both kidneys are characteristics of autosomal dominant polycystic kidney disease (ADPKD), resulting in an increase in kidney volume. Healthy kidney tissue is compressed by the cysts, causing progressive decline in kidney function and, in the majority of patients, leading to the need for renal replacement therapy. Total kidney volume (TKV) has been ... Read More »

Clinical Outcomes Not Improved with More Frequent and Longer Hemodialysis Therapy

Clinical outcomes were not improved with use of more frequent and longer dialysis sessions compared with conventional hemodialysis therapy. Earlier initiation of dialysis therapy was also not associated with improvements in outcomes. Those were among the findings of a systematic review and evidence synthesis conducted recently by Yelena Slinin, MD, and colleagues. The researchers reported results in the American Journal ... Read More »

Warfarin Use in Hemodialysis Patients with Atrial Fibrillation

Warfarin use in hemodialysis patients with incident atrial fibrillation (AF) was marginally associated with reduced risk of ischemic stroke in a study conducted recently by Jenny I. Shen, MD, MSc, and colleagues. The researchers reported results of the retrospective observational cohort study in the American Journal of Kidney Diseases [2015;66(4):677-688]. AF affects an estimated 2.7 million Americans. Independent risk factors ... Read More »

Physical Functional Status Associated with Improved Survival Rate Among Transplant Recipients

For patients wait-listed for a kidney transplant, functional status may help in determining which patients will derive a benefit from transplantation compared with continued maintenance dialysis therapy. That was among the findings of a retrospective cohort study conducted recently by Peter P. Reese, MD, MSCE, and colleagues [Am J Kidney Dis. 2015;66(5):837-845]. Healthcare providers face continuing challenges in assessing the ... Read More »

Patients with CKF Experience Reduced Cardiovascular Reserve

In patients with chronic kidney failure (CKF), maladaptive left ventricular (LV) changes and blunted chronotropic response are important factors that result in reduced cardiovascular reserve. That was among the findings of a recent study conducted by Stephen M. S. Ting, PhD, and colleagues. Dr. Ting et al reported results of the prospective matched-cohort study in the American Journal of Kidney ... Read More »

Gait Speed and Risk of Mortality and Hospitalization among Hemodialysis Patients

Because walking involves the heart, lungs, and circulatory, nervous, and musculoskeletal systems, gait speed is an important marker of health status. Nancy G. Kutner, PhD, and colleagues recently conducted a prospective cohort study designed to test the hypothesis that (1) gait speed <0.6 meters per second (m/s) would be associated with increased risk of mortality among patients receiving hemodialysis, and ... Read More »