Conference Coverage

RP-103 Promotes Growth in Treatment-Naïve Patients ≤6 Years

New Orleans—Nephropathic cystinosis (NC) is a recessive disease in which the lysosomal cysteine exporter is deficient, causing accumulation of intralysomal cysteine; in addition, the biomarker WBC ½ cysteine/mg protein is >1 nmol. Cysteamine bitartrate (Cys-Bi) lowers levels to <1 nmol. Researchers in Brazil conducted a long-term, prospective, controlled, open-label trial of RP-103. Study participants were 17 Cys-Bi naïve patients with ... Read More »

Serum Levels of Uric Acid and Complement C3 Associated with Renal Arteriosclerosis

New Orleans—Previous studies have demonstrated that hyperuricemia (HUA) is related to renal arteriosclerosis in patients with chronic kidney disease (CKD). Researchers in Japan recently examined the significance of concurrent occurrence of HUA and elevated levels of serum complement C3 (C3). The study involved 172 patients with CKD. The mean arteriolar hyalinization grade following HC3/HUA subgrouping and after logarithmic transformation, was ... Read More »

Association Between Blood Pressure and High Uric Acid in CKD Patients

New Orleans—Patients with chronic kidney disease (CKD) with high levels of serum uric acid may be susceptible to hypertensive renal damage. However, according to researchers, there are few data on the effects of high serum uric levels on the relationship between blood pressure levels and proteinuria in CKD. In a recent Japanese study, 109 patients with non-nephrotic CKD who underwent ... Read More »

Early Hospitalization after Dialysis Initiation Increases Risk of All-Cause Mortality

New Orleans—Within the first several months of dialysis initiation, rates of hospitalization and mortality are relatively high, but there are few data available on the association between early hospitalization following dialysis initiation (within 90 days) and clinical outcomes in patients with end-stage renal disease. In a recent study, participants (n=1584) were selected from the Clinical Research Center registry, a prospective ... Read More »

Uric Acid and Renal Pathological Features

New Orleans—Patients with chronic kidney disease (CKD) commonly develop hyperuricemia, which increases the risk of cardiovascular events and accelerates CKD progression. Chinese researchers conducted a study to identify the relationship between baseline uric acid levels and renal pathological features. The study included 1070 patients who underwent renal biopsy at a single center. Of the 1070 patients, 429 were IgA nephropathy ... Read More »

Stem Cell Transplant for Refractory Lupus Nephritis

of treating patients with refractory lupus nephritis with autologous hematopoietic stem cell transplantation (ASCT). Twenty-two patients were enrolled in the study between June 2011 and January 2015; inclusion criteria were relapse of refractory lupus nephritis or lack of response to standard immunosuppression therapies. Of the nine men and 13 women in the study cohort, median duration of lupus nephritis was ... Read More »

Genetics of Gout in Patients with CKD

New Orleans—The most common inflammatory arthritis with a strong genetic component worldwide is gout. Patients with chronic kidney disease (CKD) are a high risk for gout, and there are limited data on the genetic risk factors for gout and their interactions with clinical factors in CKD. German researchers performed genome-wide association studies of serum urate and gout in 4941 patients ... Read More »

International Registry of Families with ADTKD Separates Subgroups

New Orleans—The clinical characteristics and diagnostic criteria of various subgroups of patients with autosomal dominant tubulointerstitial kidney disease (ADTKD) are not well defined. A recent international project created a registry of 463 families diagnosed with ADTKD. Index cases were screened for UMOD mutations, followed by MUC1, HNF1B, and REN mutations in families without ADTKD. Results were reported during a poster ... Read More »

Hyperuricemia and Gout Common in Renal Transplant Recipients

New Orleans—As many as 28% of kidney transplant recipients experience hyperuricemia and gout, due, in part, to reduced excretory renal function, intake of diuretic medications, and side effects of immunosuppression drugs. In a poster session at Kidney Week, results of clinical experience with anti-interleukin-1 (IL-1) antibody treatment in three renal transplant recipients with refractory gout arthritis despite various treatment regimens ... Read More »

Emergency Hospitalization Rates for Hemodialysis versus Peritoneal Dialysis Patients

New Orleans—A recent retrospective observational study evaluated 13,078 hospitalizations of patients with end-stage renal disease receiving either hemodialysis (n=1995) or peritoneal dialysis (n=497) therapy to define associations between dialysis modality and emergency hospitalizations for cardiovascular diseases (hemodialysis, 1704; peritoneal dialysis, 261 times) and infectious diseases (excluding infections related to peritoneal dialysis; hemodialysis 970; peritoneal dialysis 132 times) at a single ... Read More »