Conference Coverage

Waist-to-Hip Ratio Predictor of Sudden Cardiac Death in Hemodialysis Patients

New Orleans—In the general population, waist-to-hip ratio (WHR) is a predictor of cardiovascular disease and mortality. In a recent study, researchers examined the association of WHR and the risk of mortality in patients with chronic kidney disease; sudden cardiac death among end-stage renal disease patients receiving hemodialysis was of particular interest. The study included 379 incident hemodialysis patients enrolled in ... Read More »

Podocyte Function Compromised with CaMK4

New Orleans—Podocyte dysfunction is a common feature of renal injury in autoimmune or non-autoimmune kidney diseases, and the good target of proteinuric kidney disease. Researchers in Boston conducted a study to test the hypothesis that targeted delivery of calcium/calmodulin-dependent kinase IV (CaMK4) inhibitor (KN93) to podocytes would preserve podocyte function. Podocytes from lupus-prone or lipopolysaccharide (LPS)-or adriamycin-treated mice and patients ... Read More »

Urine Soluble CD163 Is a Biomarker of Active Nephrotic Syndrome

New Orleans—Urinary soluble CD163 (usCD163) displays excellent biomarker characteristics for detection of active renal vasculitis in patients with ANCA-associated vasculitis and lupus. Fifty-three patients were included in a recent study designed to examine the levels of usCD163 in active and remission nephrotic syndrome. Of the 53 participants, 22 had membranous glomerulonephritis (MN), 20 had minimal change (MCD), and 11 had ... Read More »

AKI Strong Risk Factor for Mortality in Influenza

New Orleans—Following a pandemic of influenza A(H1N1) in 2009 in Mexico, reports described the presentation of influenza in critically ill patients; there was a high prevalence of acute kidney injury (AKI) and mortality in the reports. In a retrospective, observational study of patients admitted to the intensive care unit (ICU) during the 2016-1027 influenza season, researchers aimed to assess AKI ... Read More »

Following Adjustment for Gout, Recurrent Kidney Stone Formers at Risk for ESRD

New Orleans—In a cohort of 7036 kidney stone formers and 28,136 controls, patients with recurrent kidney stones, but not those with incident kidney stones, were at higher risk of end-stage renal disease and mortality compared with the control group, following adjustment for baseline chronic kidney disease, diabetes mellitus, hypertension, dyslipidemia, obesity, and gout. Patients with asymptomatic kidney stones were also ... Read More »

Vascular Access in the Elderly

New Orleans—Individuals ≥75 years of age represent >57% of patients receiving maintenance dialysis. Arteriovenous fistulas (AVF) have the lowest rates of morbidity and mortality and are the preferred vascular access for hemodialysis; it is unclear, however, that AVF is the optimal access in the elderly. A retrospective study evaluated outcomes in patients who underwent surgery for the creation of a ... Read More »

Central Adiposity in Patients with Type 1 Diabetes and Diabetic Nephropathy

New Orleans—In both the general population and in patients with type 1 diabetes, central adiposity is a key risk factor for cardiorenal risk. A recent study was designed to assess the relationship between central adiposity and renal hemodynamic function in adults with longstanding type 1 diabetes (n=75, duration >50 years) and without diabetic nephropathy (controls; n=75). In the control group, ... Read More »

Kidney Transplant Outcomes in Patients with RPGN

New Orleans—The primary causes of end-stage renal disease (ESRD) due to rapidly progressive glomerulonephritis (RPGN) are antineutrophil cytoplasmic autoantibodies (ANCA) associated vasculitis (AAV) and anti-glomerular basement membrane (anti-PBM). Researchers at the School of Medicine and Public Health at the University of Wisconsin, Madison, reported long-term in renal transplant recipients with EDRS due to RPGN. Outcomes for patients with ESRD due ... Read More »

RP-103 Promotes Growth in Treatment-Naïve Patients ≤6 Years

New Orleans—Nephropathic cystinosis (NC) is a recessive disease in which the lysosomal cysteine exporter is deficient, causing accumulation of intralysomal cysteine; in addition, the biomarker WBC ½ cysteine/mg protein is >1 nmol. Cysteamine bitartrate (Cys-Bi) lowers levels to <1 nmol. Researchers in Brazil conducted a long-term, prospective, controlled, open-label trial of RP-103. Study participants were 17 Cys-Bi naïve patients with ... Read More »

Serum Levels of Uric Acid and Complement C3 Associated with Renal Arteriosclerosis

New Orleans—Previous studies have demonstrated that hyperuricemia (HUA) is related to renal arteriosclerosis in patients with chronic kidney disease (CKD). Researchers in Japan recently examined the significance of concurrent occurrence of HUA and elevated levels of serum complement C3 (C3). The study involved 172 patients with CKD. The mean arteriolar hyalinization grade following HC3/HUA subgrouping and after logarithmic transformation, was ... Read More »