Kidney Week 2018

Urinary Oxalate Excretion Associated with Risk of Progression of CKD and ESRD

San Diego—Oxalate nephropathy, a complication of oxalate metabolism (primary hyperoxaluria), oxalate over-absorption (enteric hyperoxaluria), and ingestion of large amounts of oxalate or its precursors, results in kidney failure. Sushrut S. Waikar, MD, and colleagues conducted an analysis to test the hypothesis that there would be an association between progression of chronic kidney disease (CKD) and higher urinary oxalate excretion, even ... Read More »

Post Hoc Analysis: Patiromer Safe and Effective in Patients with Diabetes Mellitus

San Diego—Researchers, led by Patrick Rossignol, MD, PhD, recently conducted a post-hoc pooled analysis to examine the efficacy and safety of patiromer for the treatment of hyperkalemia in patients with and without diabetes mellitus. The researchers reported results of the analysis during a poster session at Kidney Week 2018 in a poster titledEfficacy and Safety of Patiromer in Participants with ... Read More »

Use of a Patient Portal Decreases Hospital Admission Rates

San Diego–Clinical status of patients on peritoneal dialysis are commonly assessed only once a month, limiting the clinician’s view of the state of the patient’s health. A large dialysis provider has launched a connected health program to enable patients on peritoneal dialysis to enter their clinical parameters or concerns daily. The portal provides automated alerts to clinicians for abnormal findings; ... Read More »

Economic Gains with Implementation of a Fluid Management Quality Initiative

San Diego—According to data from the US Renal Data System, there are more than 100,000 new hemodialysis patients per year. For patients initiating hemodialysis, the first 90 days are associated with increased rates of hospitalization and mortality, in addition to high healthcare costs. Melissa M. Rosen, MPH, PhD, and colleagues recently conducted an economic analysis of data on incident hemodialysis ... Read More »

Lower ScvO2 and Higher Relative Blood Volume Associated with Higher Mortality Risk

San Diego—Clinicians are increasingly conducting monitoring of relative blood volume (RBV) and central venous oxygen saturation (ScvO2) in hemodialysis patients. Researchers previously demonstrated that, at higher levels of SCVO2, RBV had only a small effect on risk of mortality; however, at lower ScvO2 levels, RBV tended to drive mortality risk. Hanjie Zhang and colleagues recently conducted a retrospective multicenter cohort ... Read More »

Data from the FOURNIER TRIAL: Efficacy and Safety of Evolocumab

San Diego—The FOURIER trial was designed to assess the efficacy and safety of evolocumab in PCSK9 inhibition in patients with chronic kidney disease (CKD); the study analyzed outcomes by kidney function. David M. Charytan, MD, and colleagues reported results of the trial during an oral session at Kidney Week 2018. The session was titled Efficacy and Safety of Evolocumab in ... Read More »

Hospitalization Rates among Patients in Fluid Management Quality Improvement Project

San Diego—The rates of hospitalization and mortality among patients receiving hemodialysis are high compared with the general population; the higher rates are particularly seen in the first 90 days of hemodialysis therapy. Nine dialysis facilities conducted a clinic-wide fluid management quality improvement (QI) project utilizing relative blood volume monitoring (RBV-M). Paul Balter, MD, and colleagues conducted a retrospective analysis of ... Read More »

Fluid Management Quality Improvement Project Using Relative Blood Volume Monitoring

San Diego—Patients receiving hemodialysis at 20 Renal Research Institute clinics participated in a 1-year fluid management quality improvement (QI) project utilizing relative blood volume monitoring (RBV-M). Paul Balter, MD, and colleagues conducted a retrospective database analysis to examine changes in body weight and blood pressure in the participating patients. Results of the analysis were reported during a poster session at ... Read More »

TRC101 to Treat Patients with Chronic Kidney Disease and Metabolic Acidosis

San Diego—The risk of chronic kidney disease (CKD) progression is increased in patients with metabolic acidosis, and metabolic acidosis adversely affects muscle and bone. TRC101, a non-absorbed , sodium-free polymeric drug that selectively binds and removes hydrochloric acid from the gastrointestinal tract, is being developed to treat metabolic acidosis and slow the progression of CKD. Donald E. Wesson, MD, MBA, ... Read More »

Burden of Kidney Stone Disease in Patients with Enteric Hyperoxaluria

San Diego—Hyperoxaluria, a serious metabolic disorder, is a key risk factor for progression of kidney stone disease and other renal complications. Patients with malabsorptive gastrointestinal conditions, such as bariatric surgery or Crohn’s disease, are at risk of developing enteric hyperoxaluria due to over-absorption of oxalate. Current standard-of-care interventions are non-specific, and many have persistently high urine oxalate levels. There are ... Read More »