Kidney Week 2017

Retention of Uric Acid Transporters and Hyperuricemia in ADTKD

New Orleans—Uromodulin (UMOD) mutations cause autosomal dominant tubulointerstitial kidney disease (ADTKD). Patients with ADTKD-UMOD generally show hyperuricemia in childhood and progression to renal failure in the course of the disease. UMOD has been localized to the proximal tubulus and uric acid transponders have been localized to the distal proximal tubulus. UMOD WT interacts with the uric acid transporters ABCG2, URAT1, ... Read More »

Predicting Renal Survival in Diabetic Nephropathy

New Orleans—The ability to predict progression of renal disease in patients with diabetes is limited, despite the identification of risk factors that include glycemic control, blood pressure, and albuminuria. Researchers conducted a study to examine the relationship between the Renal Pathology Society pathologic classification system score and progression of diabetic renal disease. Of 394 biopsies performed at St. Michael’s Hospital, ... Read More »

Pathways Associated with Hyperuricemia in Hispanic Children

New Orleans—Hyperuricemia in children is known to be predictive of hypertension in adulthood. Researchers studied 260 Hispanic children (130 with hyperuricemia and 130 without hyperuricemia) from the Viva La Familia study to identify urinary metabolites and pathways associated with hyperuricemia. A total of 703 metabolites were identified; of those, 377 were significantly different between the two groups. Key differences were ... Read More »

Pegloticase Decreases in MAP in Patients with Chronic Gout

New Orleans—In an analysis of results from randomized clinical trials of pegloticase, researchers examined the impact of persistent, very low levels of serum uric acid on blood pressure in patients with chronic refractory gout. The analysis included data on 29 responders whose mean arterial pressure (MAP) at baseline was 94.9 mm Hg. Throughout the 6-month trial, there were significant reductions ... Read More »

ADPKD Patients with Advanced CKD at Increased Risk of Adverse Outcomes

New Orleans—Patients with autosomal dominant polycystic kidney disease (ADPKD) develop progressive chronic kidney disease (CKD) and a subsequent increased risk for adverse events that include cardiovascular disease, infections, end-stage renal disease (ESRD), and mortality. There are few data available on the risks of adverse events in patients with ADPKD and advanced CKD. Manish M. Sood, MD, and colleagues conducted a ... Read More »

Fluid Overload and AKI and Mortality in Influenza Patients

New Orleans—In a subset of critically ill patients with influenza, particularly A(H1N1), the influenza virus has been consistently associated with high mortality in patients who develop Acute Distress Respiratory Syndrome (ADRS).  There are few available data on the risk factors for this association. There have been studies documenting the association of fluid overload and an increase in the incidence of ... Read More »

Identifying Rapid Progression in Patients with ADPKD

New Orleans—The most frequently inherited kidney disease is autosomal dominant polycystic kidney disease (ADPKD). The progressive cyst growth associated with ADPKD, combined with interstitial damage, causes progressive kidney failure; there is wide variation of the severity of ADPKD among this patient population. The European Medicines Agency has approved tolvaptan for adults with CKD stage 1 to 3 at baseline who ... Read More »

Predicting Hyponatremia from Electronic Medical Records

New Orleans—In both hospitalized and ambulatory patients, hyponatremia is associated with increased morbidity and mortality. Utilizing electronic medical records (EMRs) to identify patients at high risk for hyponatremia may have significant impact on patient outcomes, according to Young-Il Jo, MD, and Sug kyun Shin, MD. Identification of high-risk patients can also serve to support clinical decision making the management of ... Read More »

Biomarkers for Early Diagnosis of AKI in Critically Ill Patients

New Orleans—Hospitalized patients may experience acute kidney injury (AKI), a condition that is more common among patients in the intensive care unit (ICU). Serum creatinine measurement can be used to assess AKI; however, according to Luana A. Pedroso, MD, and colleagues, serum creatinine is a poor and delayed marker of AKI. In recent decades, new circulating and urinary biomarkers have ... Read More »

Pathways and Biomarkers for Progression of Diabetic Kidney Disease

New Orleans—The leading cause of end-stage renal disease (ESRD) is diabetic kidney disease. According to researchers, understanding of molecular pathways involved in the initiation and progression of diabetic kidney disease facilitates development of biomarkers and identification of drug targets. Skander Mulder, MD, and colleagues conducted a study designed to identify molecular pathways associated with progressive loss of kidney function in ... Read More »