Abstract Roundup

AKI Subphenotypes and Response to Vasopressin Therapy

American Journal of Respiratory and Critical Care Medicine. doi.org/10.1164/rccm.201807-13460C Results of a study designed to identify and test whether acute kidney injury (AKI) subphenotypes have prognostic and therapeutic implications were reported by Pavan K. Bhatraju, MD, and colleagues. Latent class analysis methodology was applied independently in two critically ill populations (discovery, n=794, and replication, n=425) with AKI. AKI subphenotypes were ... Read More »

December 2018: Abstract Round Up

AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE Macrophage-Dependent Cyst Growth and Mcp1 Upregulation Journal of the American Society of Nephrology. doi.org/10.1681/ASN.201850518 Most patients with autosomal dominant polycystic disease (ADPKD) have a mutation in PKD1 or PKD2. In those patients, abnormally large numbers of macrophages accumulate around kidney cysts, promoting their growth. Previous research has suggested that monocyte chemoattractant protein-1 (Mcp1) may be ... Read More »

October 2018: Abstract Round Up

ACUTE KIDNEY INJURY Liver Transplant Outcomes Worsen with AKI Journal of Intensive Care Medicine. doi.org/10.1177/0885066618790558 Both prior to and following liver transplant, the development of acute kidney injury (AKI) in the setting of liver disease is a significant event. AKI may be the cause of worse outcomes or may merely be associated with worse outcomes; the occurrence of renal failure ... Read More »

September 2018: Abstract Roundup

ACUTE KIDNEY INJURY Study Underway to Examine Incidence of CKD after AKI in the ICU Annals of Intensive Care. doi.org/10.1186/s13613-018-0421-7 Acute kidney injury (AKI) among patients in the intensive care unit (ICU) is associated with poor outcomes, including short- and long-term mortality, as well as increased risk of chronic kidney disease (CKD) in non-ICU patients. Guillaume Geri, MD, PhD, and ... Read More »

July/August 2018: Abstract Roundup

ACUTE KIDNEY INJURY Renal Resistive Index as Early Biomarker of AKI Journal of Cardiothoracic and Vascular Anesthesia. doi.org/10.1053/j.jvca.2018.04.014 Renal resistive index (RRI), determined by intraoperative Doppler, seems to be a promising early biomarker of acute kidney injury (AKI). As RRI is studied, the ease, efficiency, and precision with which it can be interpreted will be linked to its clinical usefulness ... Read More »

May/June 2018: Abstract Roundup

Rates of AKI Lower with TAVR versus SAVR Nephrology Dialysis Transplantation. doi.org/10.1093/ndt/gfy097 In randomized trials, rates of acute kidney injury are lower with transcatheter aortic valve replacement (TAVR) compared with surgical aortic valve replacement (SAVR). There are limited nationally representative real-world data on the comparative rates of AKI for TAVR versus SAVR and predictors and prognostic implications of AKI after ... Read More »

April 2018: Abstract Roundup

CHRONIC KIDNEY DISEASE Nondepressive Psychosocial Factors and Risk of CKD in Black Americans Clinical Journal of the American Society of Nephrology. 2018;13(2):213-222 Researchers led by Joseph Lunyera, MD conducted a study to examine the association of nondepressive psychosocial factors with risk of chronic kidney disease (CKD) among black Americans. Data from the Jackson Heart Study were utilized for the current ... Read More »

March 2018: Abstract Roundup

Recurrent AKI Episodes Associated with Relevant Complications Kidney Blood Pressure Research. https://doi.org.10.1159/000486744 Following a first incidence of acute kidney injury (AKI) related to hospitalization, patients often experience recurrent AKI; however, there are few data available regarding the prognosis of recurrent episodes of AKI in the development of chronic kidney disease (CKD), cardiovascular events, and mortality. Eva Rodriguez, MD, PhD, and ... Read More »

February 2018: Abstract Roundup

High Levels of Serum Triglycerides Associated with Incidence and Progression of CKD Journal of Renal Nutrition. 2107;27(6):381-394 There are few data available on the association of serum triglycerides (TGs) and consumption of alcohol with chronic kidney disease (CKD). Kazuhiko Tsuruya, MD, PhD, and colleagues conducted a longitudinal cohort study designed to examine the association of TGs and alcohol consumption with ... Read More »

November 2017: Abstract Roundup

Chronic Kidney Disease Direct-Acting Antiviral HCV  Treatment Safe and Effective in CKD Patients Clinical Journal of the American Society of Nephrology. doi:10.2215/CJN.02510317 Patients with chronic kidney disease (CKD) commonly present with hepatitis C virus (HCV) infection, a complication that can lead to accelerated progression to end-stage renal disease. Sofosbuvir, a direct-acting antiviral agent, is known to be effective and safe ... Read More »