Abstract Roundup

July / August 2019 Abstract Roundup

CHRONIC KIDNEY DISEASE Conservative Kidney Management Recommendations for Patients with CKD Clinical Journal of the American Society of Nephrology. doi.org/10.2215/CJN.10510917 For patients with estimated glomerular filtration rate category 5 chronic kidney disease (CKD) who are deemed unlikely to benefit from dialysis and/or who choose a nondialysis option, conservative kidney management is increasingly accepted as an appropriate treatment option. However, according ... Read More »

May / June 2019 Abstract Roundup

Acute Kidney Injury Study Examines Risk Factors for Neonatal AKI Clinical Journal of the American Society of Nephrology. 2019;14(2):183-195 Poor short- and long-term outcomes are associated with neonatal acute kidney injury (AKI). Jennifer R. Charlton, MD, and colleagues recently conducted a an international retrospective observational cohort study designed to examine the risk factors and outcomes of neonatal AKI in the ... Read More »

April 2019 Abstract Roundup

CHRONIC KIDNEY DISEASE Possible Beneficial Effect of Statin Therapy on Iron Metabolism in Patients with CKD Renal Failure. doi:10.1080/0886022X.2018.1535983 Anna Masajtis-Zagajewska, MD, PhD, and colleagues conducted a double blind, randomized crossover study designed to examine the effect of 6-month administration of atorvastatin on hepcidin and hemojuvelin levels, inflammatory parameters, and iron metabolism in patients with chronic kidney disease (CKD) stages ... Read More »

March 2019: Abstract Roundup

ADPKD Journal of the American Society of Nephrology. 2018;29(10):2593-2600 Estimates of Prevalence of Polycystic Kidney Disease Using Population Sequencing It is difficult to estimate the prevalence of autosomal dominant polycystic kidney disease (ADPKD). Early studies put the lifetime risk of ADPKD at about one per 1000 in the general population; however, recent epidemiologic studies found a point prevalence of three ... Read More »

AKI Subphenotypes and Response to Vasopressin Therapy

American Journal of Respiratory and Critical Care Medicine. doi.org/10.1164/rccm.201807-13460C Results of a study designed to identify and test whether acute kidney injury (AKI) subphenotypes have prognostic and therapeutic implications were reported by Pavan K. Bhatraju, MD, and colleagues. Latent class analysis methodology was applied independently in two critically ill populations (discovery, n=794, and replication, n=425) with AKI. AKI subphenotypes were ... Read More »

December 2018: Abstract Round Up

AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE Macrophage-Dependent Cyst Growth and Mcp1 Upregulation Journal of the American Society of Nephrology. doi.org/10.1681/ASN.201850518 Most patients with autosomal dominant polycystic disease (ADPKD) have a mutation in PKD1 or PKD2. In those patients, abnormally large numbers of macrophages accumulate around kidney cysts, promoting their growth. Previous research has suggested that monocyte chemoattractant protein-1 (Mcp1) may be ... Read More »

October 2018: Abstract Round Up

ACUTE KIDNEY INJURY Liver Transplant Outcomes Worsen with AKI Journal of Intensive Care Medicine. doi.org/10.1177/0885066618790558 Both prior to and following liver transplant, the development of acute kidney injury (AKI) in the setting of liver disease is a significant event. AKI may be the cause of worse outcomes or may merely be associated with worse outcomes; the occurrence of renal failure ... Read More »

September 2018: Abstract Roundup

ACUTE KIDNEY INJURY Study Underway to Examine Incidence of CKD after AKI in the ICU Annals of Intensive Care. doi.org/10.1186/s13613-018-0421-7 Acute kidney injury (AKI) among patients in the intensive care unit (ICU) is associated with poor outcomes, including short- and long-term mortality, as well as increased risk of chronic kidney disease (CKD) in non-ICU patients. Guillaume Geri, MD, PhD, and ... Read More »

July/August 2018: Abstract Roundup

ACUTE KIDNEY INJURY Renal Resistive Index as Early Biomarker of AKI Journal of Cardiothoracic and Vascular Anesthesia. doi.org/10.1053/j.jvca.2018.04.014 Renal resistive index (RRI), determined by intraoperative Doppler, seems to be a promising early biomarker of acute kidney injury (AKI). As RRI is studied, the ease, efficiency, and precision with which it can be interpreted will be linked to its clinical usefulness ... Read More »

May/June 2018: Abstract Roundup

Rates of AKI Lower with TAVR versus SAVR Nephrology Dialysis Transplantation. doi.org/10.1093/ndt/gfy097 In randomized trials, rates of acute kidney injury are lower with transcatheter aortic valve replacement (TAVR) compared with surgical aortic valve replacement (SAVR). There are limited nationally representative real-world data on the comparative rates of AKI for TAVR versus SAVR and predictors and prognostic implications of AKI after ... Read More »