Author Archives: Shane Whitney

Kidney Transplantation Outcomes in Patients with ADPKD

For patients with end-stage renal disease (ESRD), the optimal choice for renal replacement therapy is renal transplant. A common cause of ESRD is the genetic disorder autosomal dominant polycystic kidney disease (ADPKD). Unlike other causes of ESRD, patients with ADPKD require additional pretransplant evaluation for intracranial aneurisms, cardiac manifestation, and complications involving liver and renal cysts. Outcomes of kidney transplant ... Read More »

Identifying Urine Biomarkers for Kidney Injury in Patients with IgAN

Renal pathology is critical in clinical management and prognosis in patients with immunoglobulin A nephropathy (IgAN), a primary glomerular disease commonly leading to chronic kidney disease, creating a need for reliable biomarkers for noninvasive evaluation of the kidney. Researchers at Ohio State University, Columbus, conducted a study designed to identify potential biomarkers of severity of kidney injury in patients with ... Read More »

T-Regulatory Cells and B-Regulatory Cells in Lupus Nephritis

Previous studies in patients with lupus nephritis have shown impairment in both the number and function of T-regulatory cells. Data on B-regulatory cells are limited in that patient population. Researchers at the Post Graduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India, conducted a prospective observational study of T-regulatory and B-regulatory populations in lupus nephritis as well as their ... Read More »

IgAN Diagnosis and Treatment in Patients with and Without Diabetes Mellitus

IgA nephropathy (IgAN) is the most common glomerular disease worldwide. The diagnosis and management of patients with glomerular diseases such as IgAN has been complicated by the prevalence of diabetes mellitus (DM) in the United States. Manish K. Saha, MD, and colleagues at the University of North Carolina Kidney Center, Chapel Hill, North Carolina, recently conducted a study designed to ... Read More »

ROCKIES Trial Results: Roxadustat for Anemia in Dialysis-Dependent CKD Patients

Washington, DC—At Kidney Week 2019, Steven Fishbane, MD, and colleagues reported on results of the ROCKIES trial of roxadustat for use in patients with end-stage renal disease (ESRD) and anemia receiving hemodialysis. Roxadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor that stimulates erythropoiesis and improves absorption and utilization of iron. Dr. Fishbane reported ROCKIES results in an oral presentation ... Read More »

HIMALAYAS Study: Roxadustat versus Epoetin Alfa

Washington, DC—The HIMALYAYAS trial was a phase 3 study of the efficacy and safety of roxadustat in the treatment of anemia in incident dialysis patients. Roxadustat (FG-4592) is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor that stimulates erythropoiesis and regulates metabolism of iron. Results of the randomized, open-label, active-controlled study were reported during a presentation at Kidney Week 2019 by ... Read More »

December 2019: News Briefs

SymphonyRM’s AI-Powered Patient Management Program In a recent press release, SymphonyRM announced that Intermountain Healthcare is expanding its use of SymphonyRM’s HealthOS platform to provide prioritized, personalized, and proactive patient engagement for their Kidney Services organization. SymphonyRM, based in Palo Alto, California, is a privately held health-tech company helping healthcare organizations through its artificial intelligence(AI)-powered data science-driven Next Best Action ... Read More »

December 2019: Abstract Round Up

ADPKD Automated Measurement of TKV and TLV in Patients with ADPKD Journal of the American Society of Nephrology. 2019;30(8):1514-1522 In patients with autosomal dominant polycystic kidney disease (ADPKD), the formation and growth of cysts in the kidney and the liver result in progressive increases in total kidney volume (TKV) and total liver volume (TLV). Manual tracing of kidneys and livers ... Read More »

Nutritional Predictors of All-Cause Mortality in Hemodialysis Patients

Washington, DC—Patients with end-stage renal disease require close monitoring of nutrition. However, in patients on hemodialysis, obtaining adequate nutritional status while avoiding fluid overload, hyperphosphatemia, and hyperkalemia is difficult. Researchers in Korea, led by Eunjin Bae, MD, PhD, conducted a retrospective cohort study to examine the clinical significance of serum albumin and other nutritional markers in patients on maintenance hemodialysis. ... Read More »