Author Archives: Shane Whitney

Low-Level Lead Exposure Associated with Decreased Kidney Function

Although exposure to lead has decreased in recent decades, environmental exposure to lead remains a public health problem. Even at low levels of exposure, adults and children experience adverse health effects. Lead exposure occurs through ingestion of contaminated food and drinking water, and through inhalation of polluted air. Dietary contributors in Europe and the United States include cereals, leafy vegetables, ... Read More »

Physical Status Score plus Serum Albumin Level Predicts All-Cause Mortality in Hemodialysis Patients

Patients with end-stage renal disease (ESRD) commonly experience physical frailty, exhibited by reduced functional mobility and muscle weakness. Previous studies have demonstrated that at least 70% of older adults with ESRD receiving hemodialysis have physical frailty. There are strong associations between poor physical status and increased risks of adverse events and mortality in this patient population. Patients with chronic kidney ... Read More »

Effect of Primary Care CKD Registry in Public Safety-Net Healthcare Delivery

There are an estimated 20 million Americans with chronic kidney disease (CKD). Independent of age, sex, and other comorbid conditions, patients with CKD are at increased risk of a premature cardiovascular event or death compared with the general population. Patients with lower income and those in racial/ethnic minorities are more likely to have kidney failure, creating a burden on healthcare ... Read More »

Hyponatremia Increases Risk of Fractures and Osteoporosis

Austin, Texas—Hyponatremia decreases bone density, possibly through osteoclast-mediated bone resorption, and is a risk factor for fragility fractures. Kalyani Murthy, MD, and colleagues recently conducted a systematic review and meta-analysis designed to examine the effects of hyponatremia on fractures and osteoporosis. They reported results of the analysis during a poster session at the NKF 2018 Spring Clinical Meetings in a ... Read More »

CRRT to Correct Severe Hyponatremia in AKI Prior to Liver Transplant

Austin, Texas—In patients receiving a liver transplant, preoperative hyponatremia and rapid perioperative shifts in serum sodium, outcomes postoperatively may be complicated, worsening outcomes. Due to the risk of hepatic encephalopathy and osmotic demyelination syndrome (ODS), serum sodium level <120 mEq/L is considered a contraindication to liver transplantation. Pretransplant management of cirrhotic patients to prevent and safely correct severe hyponatremia is ... Read More »

Dialysis Patients with Depressive Symptoms Have Higher Hospitalization Rates

Austin—It has been previously reported that in-center hemodialysis patients with depressive symptoms are less likely to remain adherent to dialysis treatment schedules and more likely experience hospital admission. Researchers for DaVita, Inc., led by Kathryn Aebel-Groesch, MSW, LCSW, recently conducted a study to identify the incidence of depression among patients on peritoneal dialysis and home dialysis and to examine the ... Read More »

Duration of Obesity Associated with Decrease in eGFR in Pediatric Cohort Study

According to Pierluigi Marzuillo, MD, PhD, and colleagues, the doubling in the prevalence of chronic kidney disease during the past two decades may, in part, be a result of the epidemic increase of obesity. Gaining an understanding of the pathophysiology of estimated glomerular filtration rate (eGFR) in childhood obesity could enable identification of pediatric patients exposed to factors that could ... Read More »

Incidence of Post-Transplant De Novo Heart Failure Deceased from 1998 to 2010

Compared with other modes of renal replacement therapy, kidney transplantation offers improved survival and quality of life. However, life expectancy among kidney transplant recipients is lower than that in the general population. Cardiovascular disease is one factor that contributes to the increased rates of mortality in the transplant population; heart failure, myocardial infarction, and stroke occur frequently in the first ... Read More »