Author Archives: nephuser

Food Insecurity Associated with Risk for Progression of CKD

The US Department of Agriculture defines food security as a person’s perceived ability to obtain nutritious and healthy food with essential nutrients, fruits, and vegetables, and limited amounts of saturated fats, sugar, and salt for an active and healthy life. Estimates of households in America classified as food insecure in 2014 were 14.3%; food insecurity was characterized as lack of ... Read More »

KDIGO CKD Referral Guidelines: Feasibility of Adherence

Early referral of patients with chronic kidney disease (CKD) to specialist nephrology care is associated with benefits that include reduced mortality at 3 months to 5 years of follow-up, reduced costs, reduced length of stay among hospitalized patients, increased quality of life, and earlier placement of preferred dialysis access. One objective of the US Office of Disease Prevention and Health ... Read More »

CRRTnet: Observational Study of Prescription and Delivery of Continuous Renal Replacement Therapy

More than half of admission to the intensive care unit (ICU) are complicated by acute kidney injury (AKI), and approximately 5% to 6% of patients admitted to the ICU require renal replacement therapy (RRT). Among patients with hemodynamic instability, continuous RRT (CRRT) is the dialysis modality of choice in high-income nations. According to Michael Heung, MD, MS, and colleagues, there ... Read More »

Early Frequent Nephrology Care Reduces Cardiovascular Risk Factors Postdialysis

Compared with age-matched controls, patients with chronic kidney disease (CKD) face a 5- to 10-fold higher risk for cardiovascular disease, including coronary artery disease, stroke, and heart failure. Cardiovascular events are the leading cause of death in patients with CKD. Interventions aimed at controlling traditional risk factors for cardiovascular disease (hypertension, diabetes, and dyslipidemia) were not associated with improvement in ... Read More »

Effectiveness of Tolvaptan in Patients with ADPKD

New Orleans—Researchers in Japan, led by Shigeo Horie, MD, recently conducted a study designed to examine the influence of genetic factors on the efficacy of treatment with tolvaptan in patients with approved autosomal dominant polycystic kidney disease (ADPKD). They reported results during a poster session at Kidney Week 2017 in a poster titled Pharmacogenomics of Tolvaptan’s Inhibitory Effect on Kidney ... Read More »

More Intensive Blood Pressure Control Associated with Lower All-Cause Mortality Risk

Chronic kidney disease affects an estimated 26 million people in the United States and 200 million individuals worldwide. The risks for cardiovascular disease, progression to end-stage renal disease (ESRD), and mortality are increased in people with CKD. Hypertension is a risk factor for cardiovascular disease and there have been several studies designed to identify the optimal blood pressure target in ... Read More »

Biliary Tract Disease a Distinct Extrarenal Complication of ADPKD

The most common inherited kidney disease is autosomal dominant polycystic kidney disease (ADPKD), which is characterized by progressive enlargement of the kidneys with multiple bilateral cysts, leading to eventual loss of kidney function and development of end-stage renal disease in middle age. ADPKD is the primary diagnosis for 10% of patients on renal replacement therapy in the United Kingdom and ... Read More »

From the Chair: Predicting the Risk of Kidney Failure among Kidney Donors

One can only donate if this act doesn’t put one’s own health and identity in serious danger.1 While kidney donation markedly improves the lives of recipients, recent studies have shown that the long-term risk of end- stage renal disease (ESRD) among donors is about 11 times greater than that in matched healthy nondonors2. That said, the absolute 15-year risk of ... Read More »

Serum Soluble Urokinase Receptor Levels as Markers of CKD Progression Risk in Children

Children diagnosed with chronic kidney disease (CKD) face significant comorbidities and reduced life expectancy and quality of life, as well as psychosocial integration during childhood and into adulthood. The ESCAPE (Effect of Strict Blood Pressure Control and ACE Inhibition on the Progression of CRF in Pediatric Patients) trial established strict blood pressure control and antiproteinuric pharmacotherapy as the first effective ... Read More »