Author Archives: nephuser

The Case for a Paradigm Shift in the Management of Hyperkalemia for CKD Patients

Guest Contributor Jessica Coleman, MD As a practicing nephrologist, I often see chronic kidney disease (CKD) patients with hyperkalemia—defined as a serum potassium level >5.0 mEq/L. That is not surprising given that the prevalence of hyperkalemia among patients with CKD is considerably higher than in the general population—40% to 50% versus 2% to 3%.1 These patients tend to be elderly, ... Read More »

November 2017: Abstract Roundup

Chronic Kidney Disease Direct-Acting Antiviral HCV  Treatment Safe and Effective in CKD Patients Clinical Journal of the American Society of Nephrology. doi:10.2215/CJN.02510317 Patients with chronic kidney disease (CKD) commonly present with hepatitis C virus (HCV) infection, a complication that can lead to accelerated progression to end-stage renal disease. Sofosbuvir, a direct-acting antiviral agent, is known to be effective and safe ... Read More »

From the Field: More Frequent Dialysis Appears Dead for Now

I still remember the excitement expressed by our company’s first client that purchased new, smaller home dialysis machines nearly 20 years ago. While the machines were expensive and would require patients to receive more frequent treatments, the patients’ quality of life would improve significantly, according to the company’s sales representative. Instead of being tied to a standard hemodialysis machine for ... Read More »

November 2017: News Briefs

Cricket Names Danny Shapiro CBO Danny Shapiro has been named chief business officer of Cricket Health, a developer of technology-enabled care solutions for patients with chronic kidney disease and end-stage renal disease. Mr. Shapiro was most recently chief operating officer of Home Care Assistance and prior to that held the position of vice president at DaVita Kidney Care. In a ... Read More »

Study Protocol: The ACT (Active Care after Transplantation) Trial

Individuals who have undergone renal transplantation often experience low physical activity, reduced physical fitness, and reduced physical functioning. In the early stages of chronic kidney disease, patients have declines in levels of physical activity; at progression to end-stage renal disease (ESRD), physical activity levels have further declined in the majority of patients. Patients with ESRD exhibit deconditioning and reductions in ... Read More »

Everolimus Exposure Combined with Low Dose Tacrolimus for Efficacy and Safety

Immunosuppressive agents are key in ensuring long-term graft survival in renal transplant recipients. Clinicians seek to achieve a balance between a low rate of acute rejections and avoidance of toxicities related to immunosuppression. The mammalian target of rapamycin (mTOR) inhibitors bind to the immunophilin FKBP12, blocking the activity of mTOR, a serine threonine protein kinase involved in the proliferation and ... Read More »

KDIGO Recommendations for Slowing CKD Progression

New Orleans—Several measures for prevention of progression of chronic kidney disease (CKD) were included in 2012 recommendations in guidelines from Kidney Disease Improving Global Outcomes. The measures include blood pressure control, use of renin-angiotensin system inhibitors (RASi), and dietary advice. There are few data on whether the recommendations are followed in current nephrology practice. Benedict Stengel, MD, and colleagues recently ... Read More »

AKI Common in Patients Treated for Cancer

New Orleans—There is an increased risk for acute kidney (AKI) among patients being treated for cancer; however, there have been limited studies on the incidence of AKI and risk factors in the current treatment era. Researchers in Canada conducted a population-level cohort study using linked administrative databases that included all patients who initiated systemic therapy, including chemotherapy and targeted agents, ... Read More »

Food Insecurity Associated with Risk for Progression of CKD

The US Department of Agriculture defines food security as a person’s perceived ability to obtain nutritious and healthy food with essential nutrients, fruits, and vegetables, and limited amounts of saturated fats, sugar, and salt for an active and healthy life. Estimates of households in America classified as food insecure in 2014 were 14.3%; food insecurity was characterized as lack of ... Read More »

KDIGO CKD Referral Guidelines: Feasibility of Adherence

Early referral of patients with chronic kidney disease (CKD) to specialist nephrology care is associated with benefits that include reduced mortality at 3 months to 5 years of follow-up, reduced costs, reduced length of stay among hospitalized patients, increased quality of life, and earlier placement of preferred dialysis access. One objective of the US Office of Disease Prevention and Health ... Read More »