Author Archives: nephuser

Nutritional Status of Children with ESRD Varies with Renal Replacement Therapy Modality

Among pediatric patients with end-stage kidney disease (ESRD), the frequency of protein-energy malnutrition ranges from 20% to 80%, resulting in loss of lean mass, depletion of fat mass, and deceleration of growth, affecting height. Multiple factors are involved in these alterations, including hormonal imbalance, low nutrient intake, decreased residual renal function, use of renal replacement therapies (RRT), i.e., hemodialysis and ... Read More »

Hospital Readmissions among Peritoneal Dialysis Patients

Austin—Patients receiving in-center dialysis commonly require hospital readmission; however, there are few data on readmissions among patients undergoing peritoneal dialysis. Abyalew Sahlie, MD, and colleagues utilized national administrative data to examine the burden and correlates of hospital readmission among patients in the United States undergoing peritoneal dialysis. Results of the analysis were reported during a poster session at the NKF ... Read More »

Obesity and Outcomes in ESRD Patients Receiving Peritoneal Dialysis

In developed countries, since the mid-1980s the prevalence of obesity among patients with end-stage renal disease (ESRD) has increased. The increase parallels that in the general population; however, the trends in the ESRD population in the United States have been more dramatic. The difference in the trends may be explained by the increased risk for chronic kidney disease in patients ... Read More »

Nutritional Status of Children with ESRD Varies with Renal Replacement Therapy Modality

Among pediatric patients with end-stage kidney disease (ESRD), the frequency of protein-energy malnutrition ranges from 20% to 80%, resulting in loss of lean mass, depletion of fat mass, and deceleration of growth, affecting height. Multiple factors are involved in these alterations, including hormonal imbalance, low nutrient intake, decreased residual renal function, use of renal replacement therapies (RRT), i.e., hemodialysis and ... Read More »

Mortality and Cardiovascular Risk after AKI Requiring Dialysis

Among patients with end-stage renal disease (ESRD) requiring renal replacement therapy (RRT), there is a high burden of cardiovascular disease and early death; the risk is particularly high in the first year following initiation of dialysis therapy. Cardiovascular disease is a contributing factor in >50% of all deaths with known causes among patients with ESRD. Results of recent studies suggest ... Read More »

Low Protein Intake Associated with Higher Mortality Risk

Glomerular filtration rate (GFR) is a key index of kidney function. Protein intake is a major dietary modulator of GFR and standard practice calls for low protein intake to slow the progression of chronic kidney disease (CKD). Results of studies on low protein intake in kidney disease have been inconsistent regarding decline in kidney function and/or mortality over time. Massimo ... Read More »

Jackson Heart Study Post Hoc Analysis: Protein Intake and Long-Term Decline in Kidney Function

The estimated prevalence of chronic kidney disease (CKD) in the United States is 14% to 16% of the adult population. Patients with CKD commonly progress to end-stage renal disease (ESRD), requiring dialysis therapy or transplantation; CKD is associated with substantial morbidity and mortality. Diabetes and hypertension are major contributors to kidney disease; other modifiable risk factors, including diet, may be ... Read More »

Jackson Heart Study: Dietary Acid Load and Risk of CKD Progression

Results of recent studies have shown that progression of chronic kidney disease (CKD), defined by estimated glomerular filtration rate (eGFR), can be affected by acid-base status. Research, including animal studies, observational epidemiology, and small clinical trials, has examined the impact of chronic metabolic acidosis on eGFR decline in individuals with moderately impaired kidney function. Diets high in sulfur-rich protein and ... Read More »

Eculizumab Treatment More Effective in Patients with Rapidly Progressive C3 Glomerulopathy

Membranoproliferative glomerulonephritis (MPGN) has traditionally been classified into three subtypes: type I and type III, characterized by immunoglobulins and complement deposits, and type II (dense deposit disease [DDD]), defined as the presence of dense deposits in the basement membrane on electron microscopy study. A new classification has been proposed to consider the wide variety of pathologic patterns of MPGN on ... Read More »

Specialist Nephrology Care Would Decrease US Health Care Costs

The RAND Corporation has released results from a recent analysis demonstrating that providing specialized medical care and coordination in patients with reduced kidney function prior to the need for dialysis treatment could save the US health care system more than $1 billion each year. According to a press release from the RAND corporation, approximately 60% of the savings would be ... Read More »