Author Archives: Kerri Fitzgerald

Treating Hypertension in Transplant Recipients: Chlorthalidone versus Amlodipine

In kidney transplantation recipients, hypertension following the transplant has been shown to be an independent risk factor for transplant failure. Hypertension after transplantation is also associated with increased risk for cardiovascular disease and mortality. Contributors involved in development of hypertension after transplant include donor, recipient, and transplantation factors. Patients treated with calcineurin inhibitors (CNIs) have been shown to have increased ... Read More »

Cognitive Impairment Among Kidney Transplant Recipients

As many as 50% to 87% of patients on maintenance dialysis experience cognitive impairment, influencing quality of life, employment rates, adherence to treatment, hospital admissions, health care costs, morbidity, and mortality. Kidney transplantation offers advantages in quality of life and survival over dialysis, but kidney transplant recipients have several risk factors for cognitive impairment, including comorbid illness, depression, and lower ... Read More »

Fall Injury Risk in Older Adults Increases after Dialysis Therapy Initiation

Among community-dwelling older adults, falls are the leading cause of injury-related hospitalizations and may lead to disability and death. More than one in three older adults fall each year, and nearly half of those falls result in injury. Earlier studies have demonstrated that serious fall injuries commonly occur among older adults with chronic kidney disease (CKD); higher levels of albuminuria ... Read More »

Associations between eGFR and Reduced Cognitive Function Stronger in Older Individuals

Reduced estimated glomerular filtration rate (eGFR) and albuminuria have both been shown to be associated with lower cognitive performance in older individuals. The association is not consistent, however. Reduced eGFR may lead to the accumulation of neurotoxins or it may represent lifetime exposure to cardiovascular disease (CVD) risk factors to CVD itself. Albuminuria may be a biomarker of generalized endothelial ... Read More »

Complications of Urgent-Start Peritoneal Dialysis

Peritoneal dialysis offers benefits to patients with end-stage renal disease (ESRD) in terms of lifestyle flexibility and preservation of residual kidney function. However, worldwide, most patients with uremia are treated with hemodialysis. Reasons for the underutilization of peritoneal dialysis include a low level of experience initiating the modality in patients with ESRD, particularly those with severe symptoms of uremia and ... Read More »

Home Telemonitoring of Patients with Chronic Kidney Disease

Worldwide, the majority of healthcare expenditures are attributed to chronic illness. Management of patients with chronic illness involves multiple care providers, often at multiple locations. Coordination of care in the nephrology setting is particularly important; studies have documented that coordinating care between healthcare providers is associated with earlier nephrology referral, resulting in reduced morbidity, mortality, overall cost, and the number ... Read More »

Incidence of Renal Replacement Therapy in Elderly Patients in Nephrology Care

Recent estimates put the population prevalence of chronic kidney disease (CKD) in the United States at 13%. CKD affects patients of all ages, but there is a strong positive association of CKD with age; the prevalence of CKD among individuals >70 years of age is 50%. Among elderly patients diagnosed with stable CKD stage 3, management by the primary care ... Read More »

PCI versus Optimal Medical Management in Patients with Advanced Chronic Kidney Disease

Coronary artery disease is a common comorbidity in individuals with advanced chronic kidney disease (CKD). Patients with CKD and coronary artery disease may benefit from cardiovascular procedures, such as percutaneous coronary intervention (PCI), that require use of intravenous contrast. However, use of contrast dye may result in contrast-induced nephrology (CIN). In patients with advanced CKD, CIN may precipitate the need ... Read More »

September 2017: Abstract Roundup

ACUTE KIDNEY INJURY Diagnoses Associated with Hospital-Acquired AKI Clinical Journal of the American Society of Nephrology. 2017;12(6):874-884 Researchers in France conducted a retrospective analysis of the association between hospital-acquired acute kidney injury (AKI) and each International Classification of Diseases-Tenth Revision (ICD-10) category to identify the diagnoses associated with AKI. The analysis included data on hospital stays for 126,736 unique individuals. ... Read More »

September 2017: News Briefs

Veltassa Approved in European Union Market In late July, Relypsa, Inc., announced that Veltassa® (patiromer) received approval from the European Commission for its Marketing Authorization Application. Patiromer is indicated for the treatment of hyperkalemia (elevated levels of blood potassium). Veltassa is the brand name for patiromer in both the United States and Europe; it is approved for marketing in all ... Read More »