Alcohol Consumption and Risk for CKD

GettyImages_178051505In a population-based cohort, there was an inverse association between alcohol consumption and the risk of developing chronic kidney disease (CKD). Noting that there are few data on the associations between consumption of alcohol and the risk of CKD, Sarah H. Kroning, MD, and colleagues conducted a prospective study of 5476 participants in the PREVEND (Prevention of Renal and Vascular End-Stage Disease) study.

Participants were 28 to 75 years of age free of CKD at baseline.  Participants self-reported alcohol consumption on a questionnaire; validation was conducted via serum high-density lipoprotein cholesterol. The primary study outcome was de novo CKD, defined as a combination of a creatinine-cystatin C-based estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 and/or the mean of two consecutive 24-hour urinary albumin excretions >30 mg.

Median follow-up was 10.2 years until February 2012. During four serial follow-up examinations, of the 5476 participants, 903 developed CKD. Compared with participants abstaining from alcohol, the multivariable-adjusted hazard ratios for CKD risk were 0.85 (95% confidence interval [CI], 0.69-1.04) for occasional alcohol consumption (<10 g/week); 0.82 (95% CI, 0.69-0.98) for light consumption (10-69.6 g/week); 0.71 (95% CI, 0.58-0.88) for moderate consumption (70-210 g/week); and 0.60 (95% CI, 0.42-0.86) for heavier consumption (>210 g/week) (significant trend).

There were similar inverse associations for alcohol consumption and the risk of CKD when CKD was defined as eGFR <60 m:/min/1.73 m2 or as 24-hour urinary albumin excretion >30 mg.

“Thus, in this population-based cohort, alcohol consumption was inversely associated with the risk of developing CKD, “ the researchers said.